ReviewBiological trace element research2018
The Physiological Role of Boron on Health.
Review in Biological trace element research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 270 citations in OpenAlex.
- A Comparison of Boron Supplement and Tamsulosin as Medical Expulsive Therapy for Urinary Stones After Extracorporeal Shock Wave Lithotripsy: a Randomized Controlled Clinical Trial.Biological trace element research · 2023Trial
- Dose and duration dependent effects of borax on ovarian structure and function in female rats.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Boron-doped nano-hydroxyapatite for enamel demineralization prevention and biofilm inhibition.Odontology · 2026Article
- Boron as a Context-Dependent System-Level Modulator: Mechanisms and Implications in Chronic Diseases.Biological trace element research · 2026Review
- The Biological Effects of Boron in Animals and Humans.Biological trace element research · 2026Review
- Boric Acid Stimulates Wound Closure and Modulates EMT-Related Gene Expression in HaCaT Cells.Biological trace element research · 2026Article
- Immunomodulatory effect of borax on murine hepatocellular carcinoma induced by diethylnitrosamine.Scientific reports · 2026Article
- Protective Effects of Lithium Borate on Acute Lung Injury Induced by Intestinal Ischemia/Reperfusion in Rats.ACS omega · 2026Article
- The use of minerals, plants and burnt materials in ancient medicine: Approaches to working recipes in John the Physician'sProceedings of the Geologists' Association. Geologists' Association · 2026Article
- Boric Acid Prevents MMC- and H₂O₂-Related DNA Damage: Evidence from Cytogenetic and Comet Assays.Biological trace element research · 2026Article
- Review
- Effects of Dietary Salt and Boric Acid on Milk Quality in Savak Akkaraman Sheep.Animals : an open access journal from MDPI · 2026Article
- Boron-tolerant bacteria in bioremediation: mechanisms, applications, and prospects for environmental sustainability.Sustainable microbiology · 2026Review
- The Values of Potentially Toxic Elements (PTEs) in Prescription and Non-prescription Dry Cat and Dog Diets in Turkey.Biological trace element research · 2026Article
- Role of essential and trace elements in chronic myeloid leukemia: associations with serum trace element profiles and hematological parameters.Frontiers in aging · 2026Article
- Boron in Diet and Medicine: Mechanisms of Delivery and Detection.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Boric acid-functionalized bentonite nanostructures attenuated paraquat-induced pulmonary injuries in rats.Scientific reports · 2025Article
- Borax Triggers Ferroptosis by Modulating the TfR1/GPX4/ACSL4 Pathway in Prostate Cancer Cells with Differential Androgen Sensitivity.Biological trace element research · 2025Article
- The Protective Effect of Boric Acid Against High Fructose-Induced Liver and Kidney Damage in Rats.Biological trace element research · 2025Article
- Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats.Biological trace element research · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Boron is an essential mineral that plays an important role in several biological processes. Boron is required for growth of plants, animals, and humans. There are increasing evidences of this nutrient showing a variety of pleiotropic effects, ranging from anti-inflammatory and antioxidant effects to the modulation of different body systems. In the past few years, the trials showed disease-related polymorphisms of boron in different species, which has drawn attention of scientists to the significance of boron to health. Low boron profile has been related with poor immune function, increased risk of mortality, osteoporosis, and cognitive deterioration. High boron status revealed injury to cell and toxicity in different animals and humans. Some studies have shown some benefits of higher boron status, but findings have been generally mixed, which perhaps accentuates the fact that dietary intake will benefit only if supplemental amount is appropriate. The health benefits of boron are numerous in animals and humans; for instance, it affects the growth at safe intake. Central nervous system shows improvement and immune organs exhibit enhanced immunity with boron supplementation. Hepatic metabolism also shows positive changes in response to dietary boron intake. Furthermore, animals and human fed diets supplemented with boron reveal improved bone density and other benefits including embryonic development, wound healing, and cancer therapy. It has also been reported that boron affects the metabolism of several enzymes and minerals. In the background of these health benefits, low or high boron status is giving cause for concern. Additionally, researches are needed to further elucidate the mechanisms of boron effects, and determine the requirements in different species.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.