Evidence map›Paper›PMID 29546243›Full record

ArticleScience advances2018

Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors.

Ariel Talavera, Jelle Hendrix, Wim Versées, Dukas Jurėnas, Katleen Van Nerom, Niels Vandenberk, Ranjan Kumar Singh, Albert Konijnenberg, Steven De Gieter, Daniel Castro-Roa and 7 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

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  8. Biochemical and X-ray analyses of the players involved in the faRel2/aTfaRel2 toxin-antitoxin operon.Acta crystallographica. Section F, Structural biology communications · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 4 countries.

Ariel TalaveraStructural Biology Brussels, Department of Bio-engineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.ORCID 0000-0002-1865-5959
Jelle HendrixMolecular Imaging and Photonics, University of Leuven, B-3001 Leuven, Belgium.ORCID 0000-0001-5731-1297
Wim VerséesStructural Biology Brussels, Department of Bio-engineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
Dukas JurėnasCellular and Molecular Microbiology, Department of Molecular Biology, Université Libre de Bruxelles, Brussels, Belgium.ORCID 0000-0003-1660-1524
Katleen Van NeromCellular and Molecular Microbiology, Department of Molecular Biology, Université Libre de Bruxelles, Brussels, Belgium.
Niels VandenberkMolecular Imaging and Photonics, University of Leuven, B-3001 Leuven, Belgium.ORCID 0000-0002-8301-0567
Ranjan Kumar SinghStructural Biology Brussels, Department of Bio-engineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.ORCID 0000-0002-6929-0670
Albert KonijnenbergStructural Biology Brussels, Department of Bio-engineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
Steven De GieterStructural Biology Brussels, Department of Bio-engineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
Daniel Castro-RoaCentre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne NE2 4AX, UK.
Anders BarthFluorescence Applications in Biology Laboratory, Department of Chemistry and Pharmacy, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID 0000-0003-3671-3072
Henri De GreveStructural Biology Brussels, Department of Bio-engineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
Frank SobottBiomolecular and Analytical Mass Spectrometry Group, Department of Chemistry, University of Antwerp, Antwerp, Belgium.ORCID 0000-0001-9029-1865
Johan HofkensMolecular Imaging and Photonics, University of Leuven, B-3001 Leuven, Belgium.ORCID 0000-0002-9101-0567
Nikolay ZenkinCentre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne NE2 4AX, UK.ORCID 0000-0003-2212-9545
Remy LorisStructural Biology Brussels, Department of Bio-engineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.ORCID 0000-0002-8862-3338
Abel Garcia-PinoCellular and Molecular Microbiology, Department of Molecular Biology, Université Libre de Bruxelles, Brussels, Belgium.ORCID 0000-0002-0634-0300
Vrije Universiteit Brussel · BEUniversité Libre de Bruxelles · BENewcastle University · GBHasselt University · BEKU Leuven · BELudwig-Maximilians-Universität München · DEUniversity of Copenhagen · DKUniversity of Leeds · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Bacterial protein synthesis is intricately connected to metabolic rate. One of the ways in which bacteria respond to environmental stress is through posttranslational modifications of translation factors. Translation elongation factor Tu (EF-Tu) is methylated and phosphorylated in response to nutrient starvation upon entering stationary phase, and its phosphorylation is a crucial step in the pathway toward sporulation. We analyze how phosphorylation leads to inactivation of

Indexed as

Protein BiosynthesisGuanosine 5'-O-(3-Thiotriphosphate)Guanosine DiphosphateModels, MolecularNucleotidesPeptide Elongation Factor TuPhosphorylationPhosphothreonineProtein BindingProtein ConformationThermodynamicsGuanosine 5'-O-(3-Thiotriphosphate)Guanosine DiphosphateNucleotidesPeptide Elongation Factor TuPhosphothreonine

Identifiers

PMID29546243
PMCPMC5851678
OpenAlexW2791262489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.