ArticleFrontiers in immunology2018
Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis.
Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 186 citations in OpenAlex.
- Trial
- Trial
- Immunomodulatory Function of Soluble Dietary Fiber: Toward Application for Prevention and Treatment of Food Allergies.Current allergy and asthma reports · 2026Review
- The effect of pectin supplementation on geriatric individuals with frailty: a randomised placebo-controlled dietary intervention study.GeroScience · 2026Article
- Dietary fiber in pediatric gastrointestinal health: a narrative review of evidence and challenges.Clinical and experimental pediatrics · 2026Review
- Pectin as a Versatile Biomaterial: Structure, Green Sourcing, and Emerging Applications in Pharmaceutics and Biomedicine.International journal of molecular sciences · 2026Review
- Diet Components, Immune Function and IgE-Mediated Food Allergy.Nutrients · 2025Review
- Breed- and Line-Dependent Severity of Inflammation and Necrosis Syndrome in AI Boars, and the Related Risk of Inflammation and Necrosis in Their Progeny.Veterinary sciences · 2025Article
- Inflammation and Necrosis Syndrome in Young Piglets-A Longitudinal Study.Veterinary sciences · 2025Article
- Review
- Prebiotics in animal nutrition: Harnessing agro-industrial waste for improved gut health and performance.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Review
- Simulated Gastrointestinal Digestion and In Vitro Fecal Fermentation of PurifiedFoods (Basel, Switzerland) · 2025Article
- The gut microbiome and dietary fibres: implications in obesity, cardiometabolic diseases and cancer.Nature reviews. Microbiology · 2025Review
- Screening of Piglets for Signs of Inflammation and Necrosis as Early Life Indicators of Animal Health and Welfare Hazards.Animals : an open access journal from MDPI · 2025Article
- Deciphering Pectin: A Comprehensive Overview of Its Origins, Processing, and Promising Utility.ACS omega · 2025Review
- Dampened TLR2-mediated Inflammatory Signaling in Bats.Molecular biology and evolution · 2025Article
- The role of plant-based dietary compounds in gut microbiota modulation in inflammatory bowel disease.Frontiers in nutrition · 2025Review
- Measuring the impact of dietary supplementation with citrus or cucumber extract on chicken gut microbiota using 16s rRNA gene sequencing.Veterinary research communications · 2024Article
- Oral Treatment with the Pectin Fibre Obtained from Yellow Passion Fruit Peels Worsens Sepsis Outcome in Mice by Affecting the Intestinal Barrier.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Exploitation of Natural By-Products for the Promotion of Healthy Outcomes in Humans: Special Focus on Antioxidant and Anti-Inflammatory Mechanisms and Modulation of the Gut Microbiota.Antioxidants (Basel, Switzerland) · 2024Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary carbohydrate fibers are known to prevent immunological diseases common in Western countries such as allergy and asthma but the underlying mechanisms are largely unknown. Until now beneficial effects of dietary fibers are mainly attributed to fermentation products of the fibers such as anti-inflammatory short-chain fatty acids (SCFAs). Here, we found and present a new mechanism by which dietary fibers can be anti-inflammatory: a commonly consumed fiber, pectin, blocks innate immune receptors. We show that pectin binds and inhibits, toll-like receptor 2 (TLR2) and specifically inhibits the proinflammatory TLR2-TLR1 pathway while the tolerogenic TLR2-TLR6 pathway remains unaltered. This effect is most pronounced with pectins having a low degree of methyl esterification (DM). Low-DM pectin interacts with TLR2 through electrostatic forces between non-esterified galacturonic acids on the pectin and positive charges on the TLR2 ectodomain, as confirmed by testing pectin binding on mutated TLR2. The anti-inflammatory effect of low-DM pectins was first studied in human dendritic cells and mouse macrophages
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.