Evidence map›Paper›PMID 29545797›Full record

ArticleFrontiers in immunology2018

Death Receptor 3 Signaling Controls the Balance between Regulatory and Effector Lymphocytes in SAMP1/YitFc Mice with Crohn's Disease-Like Ileitis.

Zhaodong Li, Ludovica F Buttó, Kristine-Anne Buela, Li-Guo Jia, Minh Lam, John D Ward, Theresa T Pizarro, Fabio Cominelli

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. TL1A/DR3 signaling deletion attenuates mucosal inflammation and alveolar bone loss in a murine model of spontaneous periodontitis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
  4. Epithelial and stromal remodeling in murine Crohn's disease-like ileitis.bioRxiv : the preprint server for biology · 2025
    Article
  5. Review
  6. Article
  7. ILC3: a case of conflicted identity.Frontiers in immunology · 2023
    Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhaodong LiBRB-5, Digestive Health Research Institute, Case Western Reserve University, Cleveland, OH, United States.
Ludovica F ButtóBRB-5, Digestive Health Research Institute, Case Western Reserve University, Cleveland, OH, United States.
Kristine-Anne BuelaDepartment of Pathology, Case Western Reserve University, Cleveland, OH, United States.
Li-Guo JiaBRB-5, Digestive Health Research Institute, Case Western Reserve University, Cleveland, OH, United States.
Minh LamBRB-5, Digestive Health Research Institute, Case Western Reserve University, Cleveland, OH, United States.
John D WardBRB-5, Digestive Health Research Institute, Case Western Reserve University, Cleveland, OH, United States.
Theresa T PizarroDepartment of Pathology, Case Western Reserve University, Cleveland, OH, United States.
Fabio CominelliBRB-5, Digestive Health Research Institute, Case Western Reserve University, Cleveland, OH, United States.
Case Western Reserve University · US

Funding

Ubiquitination Pathways Mediating Chronic Intestinal InflammationP01DK091222 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI COMINELLI, FABIO · 2011 to 2020
$16.5M
The Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Theresa Torres Pizarro · 2015 to 2026
$15.6M
MECHANISMS OF EXPERIMENTAL CROHNS DISEASER01DK055812 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO · 1999 to 2019
$4.9M
CYTOKINES AND INFLAMMATORY BOWEL DISEASER01DK042191 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO, PIZARRO, THERESA TORRES · 1995 to 2022
$4.7M
CYTOKINES AND INFLAMMATORY BOWEL DISEASER37DK042191 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO · 1999 to 2009
$3.8M
Combined Training Program in Digestive Disease SciencesT32DK083251 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI COMINELLI, FABIO, FIOCCHI, CLAUDIO · 2010 to 2025
$3.6M
Cytokines and Inflammatory Bowel DiseaseR56DK042191 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI COMINELLI, FABIO · 2010 to 2010
$504k
Mechanisms of Experimental Crohn's DiseaseR56DK055812 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI COMINELLI, FABIO, RODRIGUEZ-PALACIOS, ALEXANDER · 2021 to 2021
$403k
NIDDK NIH HHS P01 DK091222NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK042191NIDDK NIH HHS R01 DK055812NIDDK NIH HHS R37 DK042191NIDDK NIH HHS R56 DK042191NIDDK NIH HHS R56 DK055812NIDDK NIH HHS T32 DK083251
6 · The paper itself

Abstract

Death receptor 3 (DR3), a member of the tumor necrosis factor receptor (TNFR) superfamily, has been implicated in regulating T-helper type-1 (T

Indexed as

AnimalsAntibodies, MonoclonalCells, CulturedCrohn DiseaseCytokinesDisease Models, AnimalFemaleForkhead Transcription FactorsHumansIleitisMaleMembrane ProteinsMiceMice, Inbred AKRMice, KnockoutMice, TransgenicAntibodies, MonoclonalCytokinesForkhead Transcription FactorsFoxp3 protein, mouseMembrane ProteinsNuclear ProteinsReceptors, Tumor Necrosis Factor, Member 25Samp1 protein, mouseCD25+/− T cellsCrohn’s diseasedeath receptor 3ileitisinflammatory bowel diseaseinnate lymphoid cellregulatory T cellsSAMP1/YitFcTL1A

Identifiers

PMID29545797
PMCPMC5837992
OpenAlexW2791351154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.