ArticleFrontiers in human neuroscience2018
Structural Covariance of the Prefrontal-Amygdala Pathways Associated with Heart Rate Variability.
Article in Frontiers in human neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Acupuncture modulates emotional network resting-state functional connectivity in patients with insomnia disorder: a randomized controlled trial and fMRI study.BMC complementary medicine and therapies · 2024Trial
- Effects of cortisol administration on heart rate variability and functional connectivity across women with different depression histories.Behavioural brain research · 2024Trial
- The relationship between heart rate variability and eye movement characteristics in adolescents with internet gaming disorder: the mediating role of impulsivity.Frontiers in psychiatry · 2026Article
- Autonomic neuropathy is associated with an increase in type-1 cytokines in people living with HIV.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Autonomic Neuropathy Is Associated with An Increase in Type-1 Cytokines in People Living With HIV.bioRxiv : the preprint server for biology · 2025Article
- Heart rate variability: a multidimensional perspective from physiological marker to brain-heart axis disorders prediction.Frontiers in cardiovascular medicine · 2025Review
- In-silico simultaneous respiratory and circulatory measurement during voluntary breathing, exercise, and mental stress: A computational approach.PLoS computational biology · 2024Article
- Relationship between central autonomic effective connectivity and heart rate variability: A Resting-state fMRI dynamic causal modeling study.NeuroImage · 2024Article
- Heart Rate Variability as a Potential Predictor of Response to Intranasal Esketamine in Patients with Treatment-Resistant Depression: A Preliminary Report.Journal of clinical medicine · 2024Article
- Resting heart rate variability is associated with neural adaptation when repeatedly exposed to emotional stimuli.Neuropsychologia · 2024Article
- Methods for assessing change in brain plasticity at night and psychological resilience during daytime between repeated long-duration space missions.Scientific reports · 2023Article
- Neuroimaging Studies of the Neural Correlates of Heart Rate Variability: A Systematic Review.Journal of clinical medicine · 2023Review
- Gender moderates the association between resting vagally mediated heart rate variability and attentional control.Frontiers in psychiatry · 2023Article
- Article
- Degraded Psychophysiological Status in Caregivers and Human Resources Staff during a COVID-19 Peak Unveiled by Psychological and HRV Testing at Workplace.International journal of environmental research and public health · 2022Article
- Developmental Differences in Affective Representation Between Prefrontal and Subcortical Structures.Social cognitive and affective neuroscience · 2021Article
- Physiological Resonance in Empathic Stress: Insights from Nonlinear Dynamics of Heart Rate Variability.International journal of environmental research and public health · 2021Article
- Impact of sex and depressed mood on the central regulation of cardiac autonomic function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Maladaptive neurovisceral interactions in patients with Internet gaming disorder: A study of heart rate variability and functional neural connectivity using the graph theory approach.Addiction biology · 2020Article
- Entropy in Heart Rate Dynamics Reflects How HRV-Biofeedback Training Improves Neurovisceral Complexity during Stress-Cognition Interactions.Entropy (Basel, Switzerland) · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neurovisceral integration model has shown a key role of the amygdala in neural circuits underlying heart rate variability (HRV) modulation, and suggested that reciprocal connections from amygdala to brain regions centered on the central autonomic network (CAN) are associated with HRV. To provide neuroanatomical evidence for these theoretical perspectives, the current study used covariance analysis of MRI-based gray matter volume (GMV) to map structural covariance network of the amygdala, and then determined whether the interregional structural correlations related to individual differences in HRV. The results showed that covariance patterns of the amygdala encompassed large portions of cortical (e.g., prefrontal, cingulate, and insula) and subcortical (e.g., striatum, hippocampus, and midbrain) regions, lending evidence from structural covariance analysis to the notion that the amygdala was a pivotal node in neural pathways for HRV modulation. Importantly, participants with higher resting HRV showed increased covariance of amygdala to dorsal medial prefrontal cortex and anterior cingulate cortex (dmPFC/dACC) extending into adjacent medial motor regions [i.e., pre-supplementary motor area (pre-SMA)/SMA], demonstrating structural covariance of the prefrontal-amygdala pathways implicated in HRV, and also implying that resting HRV may reflect the function of neural circuits underlying cognitive regulation of emotion as well as facilitation of adaptive behaviors to emotion. Our results, thus, provide anatomical substrates for the neurovisceral integration model that resting HRV may index an integrative neural network which effectively organizes emotional, cognitive, physiological and behavioral responses in the service of goal-directed behavior and adaptability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.