ArticleCell research2018
Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases.
Article in Cell research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 120 citations in OpenAlex.
- Plant G proteins: Versatile signaling hubs for synergistic improvement of agronomic traits.Journal of integrative plant biology · 2026Review
- Genome-wide identification of maize G protein genes and regulatory roles of the ZmGG1 subfamily in saline-alkali stress response.BMC plant biology · 2026Article
- Flagellin sensing, signaling, and immune responses in plants.Plant communications · 2025Review
- Phosphorylation-activated G protein signaling stabilizes TCP14 and JAZ3 to repress JA signaling and enhance plant immunity.Molecular plant · 2025Article
- Heterotrimeric G-protein subunits regulate plant architecture, pod development, seed size, and symbiotic nodulation inaBIOTECH · 2025Article
- Plant PAQR-like sensors activate heterotrimeric G proteins to confer resistance against multiple pathogens.Molecular plant · 2025Article
- A molecular dynamics study of membrane positioning for 7-transmembrane RGS proteins to modulate G-protein-mediated signaling in plants.Computational and structural biotechnology journal · 2025Article
- VPS26 Moonlights as a β-Arrestin-like Adapter for a 7-Transmembrane RGS Protein inBiochemistry · 2024Article
- Trade-Off Regulation in Plant Growth and Stress Responses Through the Role of Heterotrimeric G Protein Signaling.Plants (Basel, Switzerland) · 2024Review
- Gγ-protein GS3 Function in Tight Genetic Relation with OsmiR396/GS2 to Regulate Grain Size in Rice.Rice (New York, N.Y.) · 2024Article
- Regulator of G protein signaling-1 regulates immune infiltration and macrophage polarization in clear cell renal cell carcinoma.International urology and nephrology · 2024Article
- Conserved Role of Heterotrimeric G Proteins in Plant Defense and Cell Death Progression.Genes · 2024Article
- TheInternational journal of molecular sciences · 2023Article
- An atypical heterotrimeric Gα and its interactome suggest an extra-large role in overcoming abiotic and biotic stress.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Review
- OsmiR159 Modulate BPH Resistance Through Regulating G-Protein γ Subunit GS3 Gene in Rice.Rice (New York, N.Y.) · 2023Article
- The woody plant-degrading pathogen Lasiodiplodia theobromae effector LtCre1 targets the grapevine sugar-signaling protein VvRHIP1 to suppress host immunity.Journal of experimental botany · 2023Article
- Identification of biomarkers differentiating Alzheimer's disease from other neurodegenerative diseases by integrated bioinformatic analysis and machine-learning strategies.Frontiers in molecular neuroscience · 2023Article
- Article
- EXTRA LARGE G-PROTEIN2 mediates cell death and hyperimmunity in the chitin elicitor receptor kinase 1-4 mutant.Plant physiology · 2022Article
- Regulation of plant responses to biotic and abiotic stress by receptor-like cytoplasmic kinases.Stress biology · 2022Review
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arabidopsis heterotrimeric G proteins regulate diverse processes by coupling to single-transmembrane receptors. One such receptor is the FLS2 receptor kinase, which perceives bacterial flagellin epitope flg22 to activate immunity through a class of cytoplasmic kinases called BIK1/PBLs. Unlike animal and fungal heterotrimeric G proteins that are activated by a ligand-induced guanine nucleotide exchange activity of seven-transmembrane G protein-coupled receptors (GPCRs), plant heterotrimeric G proteins are self-activating. How plant receptors regulate heterotrimeric G proteins in response to external ligands remains unknown. Here we show that RGS1, a GTPase accelerating protein, maintains Arabidopsis G proteins in an inactive state in complex with FLS2. Activation of FLS2 by flg22 induces a BIK1/PBL-mediated phosphorylation of RGS1 at Ser428 and Ser431 and that promotes RGS1 dissociation from the FLS2-G protein complex. This relieves G proteins from the RGS1-mediated repression and enables positive regulation of immune signaling. We additionally show that RGS1 is similarly regulated by multiple immune receptors. Our results uncover ligand-induced de-repression as a mechanism for G protein signaling in plants that is distinct from previously reported mechanism underlying the activation of heterotrimeric G proteins in other systems.
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