ArticleScientific reports2018
Sperm activation through orbital and self-axis revolutions using an artificial cilia embedded serpentine microfluidic platform.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- AI-Integrated Micro/Nanorobots for Biomedical Applications: Recent Advances in Design, Fabrication, and Functions.Biosensors · 2025Review
- Magnetic Cilia with Programmable Beating Patterns for Vortex-Driven Mixing in Microfluidics.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- In-Liquid Micromanipulation via a Magnetic Microactuator for Multitasking.Small science · 2025Article
- A Modified-Herringbone Micromixer for Assessing Zebrafish Sperm (MAGS).Micromachines · 2023Article
- Microfluidic Applications of Artificial Cilia: Recent Progress, Demonstration, and Future Perspectives.Micromachines · 2022Review
- Shape-programmable artificial cilia for microfluidics.iScience · 2021Article
- The evaluation of zebrafish cardiovascular and behavioral functions through microfluidics.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The zebrafish sperm activation profoundly depends upon the homogeneous mixing of the sperm cells with its diluent in a quick succession as it alters the cell's extracellular medium and initiates their motility. Manual stirring, the traditional method for zebrafish sperm activation is tedious, time-consuming, and has a poor outcome. In this aspect, an artificial cilia embedded serpentine microfluidic is designed through which hydrodynamic factors of the microfluidic environment can be precisely regulated to harness uniform mixing, hence ensuring a superior sperm activation. To quantify the sperm motility, computer assisted sperm analysis software (CASA) was used whereas to quantify the generated flow field, micro particle image velocimetry (μPIV) was used. With this proposed microfluidic, 74.4% of the zebrafish sperm were activated which is 20% higher than its currently existing manual measurements. The μPIV analysis demonstrates that the curvature of the microchannel induces an orbital rotation to the flow field along the length of the microchannel together with the artificial cilia actuation which instigates a local rotation to the flow field of the artificial cilia location. The collective rotation in the whole flow field induce vorticity that promotes the change in temporal dynamics of the sperm cells towards their activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.