ArticleCirculation. Genomic and precision medicine2018
Genetic Control of Left Atrial Gene Expression Yields Insights into the Genetic Susceptibility for Atrial Fibrillation.
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Article in Circulation. Genomic and precision medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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45citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 9% of its field
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- The transcriptional landscape of atrial fibrillation: A systematic review and meta-analysis.PloS one · 2025Pooled it
- PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.Nature communications · 2018Pooled it
- Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits.Heart rhythm · 2026Article
- Genomic Structural Equation Modeling Combined With Post-GWAS Analysis Identifies Two Risk Gene Loci and Functionally Sensitive Genes Associated With Cardiac Conduction Block.Genetics research · 2026Article
- A cross-tissue transcriptome-wide association study identifies novel susceptibility genes for atrial fibrillation.Journal of arrhythmia · 2025Article
- Single-nucleus multi-omics implicates androgen receptor signaling in cardiomyocytes and NR4A1 regulation in fibroblasts during atrial fibrillation.Nature cardiovascular research · 2025Article
- Review
- Connecting intermediate phenotypes to disease using multi-omics in heart failure.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2025Article
- Genetic analysis reveals the shared genetic architecture between breast cancer and atrial fibrillation.Frontiers in genetics · 2025Article
- CommonCirculation. Genomic and precision medicine · 2024Article
- Transcriptomic Insights into the Atrial Fibrillation Susceptibility Locus near theInternational journal of molecular sciences · 2024Article
- Atrial fibrillation variant-to-gene prioritization through cross-ancestry eQTL and single-nucleus multiomic analyses.iScience · 2024Article
- Connecting intermediate phenotypes to disease using multi-omics in heart failure.medRxiv : the preprint server for health sciences · 2024Article
- Advancing drug development for atrial fibrillation by prioritising findings from human genetic association studies.EBioMedicine · 2024Article
- Comprehensive mendelian randomization reveals atrial fibrillation-breast cancer relationship and explores common druggable targets.Frontiers in pharmacology · 2024Article
- Decreased FAM13B Expression Increases Atrial Fibrillation Susceptibility by Regulating Sodium Current and Calcium Handling.JACC. Basic to translational science · 2023Article
- Review
- Novel functional atrial fibrillation risk genes and pathways identified from coexpression analyses in human left atria.Heart rhythm · 2023Article
- Connecting the Dots From GWAS to Function in Atrial Fibrillation forCirculation research · 2023Article
- Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.Circulation · 2023Article
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Authors and funding
15 authors at 3 institutions in 4 countries.
Jeffrey HsuFrom the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH.
Shamone Gore-PanterFrom the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH.
Gregory TchouFrom the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH.
Laurie CastelFrom the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH.
Beth LovanoFrom the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH.
Christine S MoravecFrom the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH.
Gosta B PetterssonFrom the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH.
Eric E RoselliFrom the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH.
A Marc GillinovFrom the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH.
Kenneth R McCurryFrom the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH.
Nicholas G SmediraFrom the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH.
John BarnardFrom the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH.
David R Van WagonerFrom the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH.
Mina K ChungFrom the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH.
Jonathan D SmithFrom the Departments of Cellular and Molecular Medicine (J.H., G.T., J.D.S.), Quantitative Health Sciences (J.B.), Molecular Cardiology (S.G.-P., L.C., B.L., C.S.M., D.R.V.W., M.K.C.), Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), and Cardiothoracic Surgery (G.B.P., E.E.R., A.M.G., K.R.M., N.G.S.), Cleveland Clinic, Cleveland, OH. smithj4@ccf.org.
Norwegian Womens Public Health Association · NOLaboratory of Molecular Genetics · PLMRC Laboratory of Molecular Biology · GB
Funding
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7MClinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0MFunctional Genomics of Atrial Fibrillation in Human AtriaR01HL111314 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BARNARD, JOHN, CHUNG, MINA KAY · 2012 to 2019
$6.1MGenetics of Atrial FibrillationR01HL090620 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BARNARD, JOHN, CHUNG, MINA KAY · 2008 to 2012
$2.9MMolecular Medicine Training ProgramT32GM088088 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI SMITH, JONATHAN D · 2011 to 2020
$1.7MNCATS NIH HHS UL1 TR000439NCRR NIH HHS UL1 RR024989NHLBI NIH HHS R01 HL090620NHLBI NIH HHS R01 HL111314NIGMS NIH HHS T32 GM088088
Abstract
backgroundGenome-wide association studies have identified 23 loci for atrial fibrillation (AF), but the mechanisms responsible for these associations, as well as the causal genes and genetic variants, remain undefined.
methodsTo identify the effect of common genetic variants on gene expression that might explain the mechanisms linking genome-wide association loci with AF risk, we performed RNA sequencing of left atrial appendages from a biracial cohort of 265 subjects.
resultsCombining gene expression data with genome-wide single nucleotide polymorphism data, we found that approximately two-thirds of the expressed genes were regulated in
conclusionsWe provide a genome-wide catalog of the genetic control of gene expression in human left atrial appendage. These data can be used to confirm the relevance of genome-wide association loci and to direct future functional studies to identify the genes and genetic variants responsible for complex diseases such as AF.
Indexed as
Genetic Predisposition to DiseaseAgedAllelesAtrial FibrillationFemaleGene ExpressionGenome-Wide Association StudyGenotypeHomeodomain ProteinsHumansMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociRibonucleoprotein, U4-U6 Small NuclearSmall-Conductance Calcium-Activated Potassium ChannelsHomeodomain ProteinsKCNN2 protein, humanPRRX1 protein, humanRibonucleoprotein, U4-U6 Small NuclearSmall-Conductance Calcium-Activated Potassium ChannelsSNRNP27 protein, humanallelesatrial appendageatrial fibrillationgenomicsquantitative trait loci
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