Evidence map›Paper›PMID 29545433›Full record

ArticleBMJ case reports2018

Recurrence of eosinophilic oesophagitis with subcutaneous grass pollen immunotherapy.

Rosy Wells, A T Fox, Mark Furman

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. The Relationship Between Eosinophilic Esophagitis and Immunotherapy.Immunology and allergy clinics of North America · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Eosinophilic esophagitis during sublingual and oral allergen immunotherapy.Current opinion in allergy and clinical immunology · 2019
    Review
  11. Subcutaneous immunotherapy in patients with eosinophilic esophagitis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019
    Article
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rosy WellsPaediatric Department, West Middlesex University Hospital, Isleworth, UK.
A T FoxChildren's Allergy Service, Guys and St Thomas' NHS Trust, London, UK.
Mark FurmanPaediatric Gastroenterology, Royal Free London NHS Foundation Trust, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Case reports have described an association between oral food/aeroallergen immunotherapy with the development of eosinophilic oesophagitis (EoE). The underlying mechanism of this is poorly understood, as is the role that both food/aeroallergen sensitisation plays in the pathogenesis of EoE. Specific immunotherapy has a long-standing history of use in the management of moderate/severe seasonal allergic rhinitis (AR), caused by tree/grass pollens. Subcutaneous immunotherapy (SCIT) to grass pollen is less commonly used in children than sublingual immunotherapy (SLIT) or oral immunotherapy for practical reasons. We describe a case of a child with severe grass-pollen related AR and known, but quiescent, EoE, who developed recurrence of oesophageal symptoms on two separate occasions, coincident with the commencement of SLIT to grass pollen. He was subsequently started on SCIT to grass pollen and developed recurrence of symptoms of EoE-a phenomenon that has yet to be reported in the medical literature.

Indexed as

ChildDesensitization, ImmunologicDiagnosis, DifferentialEosinophilic EsophagitisHumansInjections, SubcutaneousMalePoaceaeRecurrenceRhinitis, Allergic, Seasonalear, nose and throatimmunological products and Vaccinesimmunologypaediatricsunwanted effects / adverse reactions

Identifiers

PMID29545433
PMCPMC5878312

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.