Evidence map›Paper›PMID 29545352›Full record

ArticleJournal of the American Society of Nephrology : JASN2018

Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms.

Yong Li, Peggy Sekula, Matthias Wuttke, Judith Wahrheit, Birgit Hausknecht, Ulla T Schultheiss, Wolfram Gronwald, Pascal Schlosser, Sara Tucci, Arif B Ekici and 6 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Alterations of Plasma Metabolites Associated with Sickle Cell Trait.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
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  7. Article
  8. Article
  9. Review
  10. The Physiological and Pathological Role of Acyl-CoA Oxidation.International journal of molecular sciences · 2023
    Review
  11. The Relationship between Changes inJournal of cardiovascular development and disease · 2023
    Review
  12. Article
  13. Article
  14. SLC26A1 is a major determinant of sulfate homeostasis in humans.The Journal of clinical investigation · 2023
    Article
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  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Yong LiInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology, and Medical Bioinformatics, and.
Peggy SekulaInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology, and Medical Bioinformatics, and.ORCID 0000-0003-2263-447X
Matthias WuttkeInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology, and Medical Bioinformatics, and.
Judith WahrheitBIOCRATES Life Sciences Aktiengesellschaft, Innsbruck, Austria.
Birgit HausknechtDepartment of Nephrology and Hypertension and.
Ulla T SchultheissInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology, and Medical Bioinformatics, and.
Wolfram GronwaldInstitute of Functional Genomics, University of Regensburg, Regensburg, Germany; and.
Pascal SchlosserInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology, and Medical Bioinformatics, and.ORCID 0000-0002-8460-0462
Sara TucciDepartment of General Pediatrics, Center for Pediatrics and Adolescent Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
Arif B EkiciInsitute of Human Genetics, University of Erlangen-Nürnberg, Erlangen, Germany.
Ute SpiekerkoetterDepartment of General Pediatrics, Center for Pediatrics and Adolescent Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
Florian KronenbergDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0003-2229-1120
Kai-Uwe EckardtDepartment of Nephrology and Hypertension and.
Peter J OefnerInstitute of Functional Genomics, University of Regensburg, Regensburg, Germany; and.
Anna KöttgenInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology, and Medical Bioinformatics, and anna.koettgen@uniklinik-freiburg.de.ORCID 0000-0002-4671-3714
GCKD Investigators
University of Freiburg · DEUniversity of Regensburg · DEBiocrates Life Sciences (Austria) · ATFriedrich-Alexander-Universität Erlangen-Nürnberg · DEInnsbruck Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acyl-CoA DehydrogenaseAdultAgedAmine Oxidase (Copper-Containing)Amino Acid Transport Systems, BasicBiological TransportCarnitineFemaleGenetic LociGenome-Wide Association StudyGlutamineHumansKidney TubulesLipid MetabolismLysineMaleacylcarnitineAcyl-CoA DehydrogenaseAmine Oxidase (Copper-Containing)Amino Acid Transport Systems, BasicAOC1 protein, humanCarnitineGlutamineLysinePutrescineSLC7A9 protein, humanchronic kidney diseasegenome-wide association studiesmetabolitesrenal tubular epithelial cells

Identifiers

PMID29545352
PMCPMC5967769
OpenAlexW2791337146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.