ArticleThe European respiratory journal2018
Multimorbidity medications and poor asthma prognosis.
Article in The European respiratory journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Asthma and Multimorbidity Amongst Ethnic Minority Groups in High Income Countries.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Review
- Coexisting Type 2 Inflammatory Conditions in Patients with Asthma Treated with Dupilumab: the RAPID Registry.Advances in therapy · 2026Observational
- Correlation ofAsia Pacific allergy · 2024Article
- Clinical inertia in asthma.NPJ primary care respiratory medicine · 2023Review
- Healthy diet associated with better asthma outcomes in elderly women of the French Asthma-E3N study.European journal of nutrition · 2022Article
- Allergic multimorbidity is associated with self-reported anaphylaxis in adults-A cross-sectional questionnaire study.Clinical and translational allergy · 2022Article
- Combinations of self-reported rhinitis, conjunctivitis, and asthma predicts IgE sensitization in more than 25,000 Danes.Clinical and translational allergy · 2021Article
- Association Between a Type 2 Inflammatory Disease Burden Score and Outcomes Among Patients with Asthma.Journal of asthma and allergy · 2021Article
- Impact of comorbid conditions on asthmatic adults and children.NPJ primary care respiratory medicine · 2020Review
- Quality of Life in Patients With Type 2 Inflammatory Asthma.Open respiratory archivesArticle
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multimedication related to multimorbidity is common in the elderly with asthma. We aimed at comprehensively characterising medications used by elderly women and assessing how multimedication impacts on asthma prognosis.We performed network-based analyses on drug administrative databases to visualise the prevalence of drug classes and their interconnections among 17 458 elderly women from the Asthma-E3N study, including 4328 women with asthma. Asthma groups sharing similar medication profiles were identified by a clustering method relying on all medications and were studied in association with adverse asthma events (uncontrolled asthma, attacks/exacerbations and poor asthma-related quality of life).The network-based analysis showed more multimedication in women with asthma than in those without asthma. The clustering method identified three multimedication profiles in asthma: "Few multimorbidity-related medications" (43.5%), "Predominantly allergic multimorbidity-related medications" (32.8%) and "Predominantly metabolic multimorbidity-related medications" (23.7%). Compared with women belonging to the "Few multimorbidity-related medications" profile, women belonging to the two other profiles had an increased risk of uncontrolled asthma and asthma attacks/exacerbations, and had lower asthma-related quality of life.The integrative data-driven approach on drug administrative databases identified specific multimorbidity-related medication profiles that were associated with poor asthma prognosis. These findings support the importance of multimorbidity in the unmet needs in asthma management.
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