Evidence map›Paper›PMID 29545171›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2018

Estrous cycle-dependent modulation of in vivo microvascular dysfunction after nanomaterial inhalation.

P A Stapleton, C R McBride, J Yi, A B Abukabda, T R Nurkiewicz

Open access · hybridAbstract read
In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Nanoparticles at the maternal-fetal interface.Molecular and cellular endocrinology · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Nanomaterial Inhalation During Pregnancy Alters Systemic Vascular Function in a Cyclooxygenase-Dependent Manner.Toxicological sciences : an official journal of the Society of Toxicology · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Maternal Engineered Nanomaterial Inhalation During Gestation Disrupts Vascular Kisspeptin Reactivity.Toxicological sciences : an official journal of the Society of Toxicology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

P A StapletonDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA; Environmental and Occupational Health Sciences Institute, Piscataway, NJ, USA. Electronic address: stapleton@eohsi.rutgers.edu.
C R McBrideDepartment of Physiology, Pharmacology, and Neuroscience, West Virginia University, Morgantown, WV, USA; Toxicology Working Group, West Virginia University, Morgantown, WV, USA.
J YiDepartment of Physiology, Pharmacology, and Neuroscience, West Virginia University, Morgantown, WV, USA.
A B AbukabdaDepartment of Physiology, Pharmacology, and Neuroscience, West Virginia University, Morgantown, WV, USA; Toxicology Working Group, West Virginia University, Morgantown, WV, USA.
T R NurkiewiczDepartment of Physiology, Pharmacology, and Neuroscience, West Virginia University, Morgantown, WV, USA; Toxicology Working Group, West Virginia University, Morgantown, WV, USA.
West Virginia University · USRutgers, The State University of New Jersey · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI PANOS G. GEORGOPOULOS · 1988 to 2026
$47.4M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Remote Microvascular Dysfunction After Particulate Matter ExposureR01ES015022 · NIEHS · WEST VIRGINIA UNIVERSITY · PI NURKIEWICZ, TIMOTHY R · 2007 to 2021
$4.9M
Mitochondrial Mechanisms, Microvascular Function, and Gestational NanotoxicologyR00ES024783 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI STAPLETON, PHOEBE · 2017 to 2019
$747k
NIEHS NIH HHS P30 ES005022NIEHS NIH HHS R00 ES024783NIEHS NIH HHS R01 ES015022NIEHS NIH HHS T32 ES007148
6 · The paper itself

Abstract

Preconceptive health encompasses male and female reproductive capability. In females, this takes into account each of the stages of the estrous cycle. Microvascular reactivity varies throughout the estrous cycle in response to hormonal changes and in preparation for pregnancy. Microvascular alterations in response to engineered nanomaterial (ENM) exposure have been described within 24-h of inhalation; however, the impact upon the uterine vasculature at differing estrous stages and at late-stage pregnancy is unclear. Female Sprague Dawley (SD) rats (virgin and late stage pregnancy [GD 19]) were exposed to nano-TiO aerosols (173.2 ± 6.4 nm, 10.2 ± 0.46 mg/m

Indexed as

Estrous CycleAdministration, InhalationAnimalsFemaleIntravital MicroscopyMicrovesselsNanostructuresPregnancyRats, Sprague-DawleyUterusBasal uterine arteriolesEngineered nanomaterialsEstrous cycleIntravital microscopyin vivoNanotoxicologyUterus

Identifiers

PMID29545171
PMCPMC6034709
OpenAlexW2793931683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.