ArticleBiological psychiatry2018
Essential Role of Ovarian Hormones in Susceptibility to the Consequences of Witnessing Social Defeat in Female Rats.
Article in Biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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Who cites it
40 citing papers in PubMed, 74 citations in OpenAlex.
- Repetitive pressure overload: species disparities, mechanisms, and translational relevance.American journal of physiology. Heart and circulatory physiology · 2026Article
- Post stress sensory contact with a male mouse is associated with altered social behavior in a female vicarious social defeat stress model.Experimental animals · 2026Article
- Impact of sex chromosomes and gonad type in stress susceptibility in corticostriatal brain regions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Not just a witness: Highlighting the utility of witness social defeat stress for the examination of neuroimmune-cardiovascular interactions across diverse populations.Neurobiology of stress · 2025Review
- The functional role of locus coeruleus microglia in the female stress response.Molecular psychiatry · 2025Article
- Oleoylethanolamide restores stress-induced prepulse inhibition deficits and modulates inflammatory signaling in a sex-dependent manner.Psychopharmacology · 2025Article
- Acute and vicarious effects of social defeat stress on social behaviour in California mice,Animal behaviour · 2025Article
- Mouse model of post-traumatic stress disorder negatively impacts cardiac homeostasis.Journal of molecular and cellular cardiology · 2025Article
- Paternal morphine alters offspring circulating beta-endorphin and corticosterone responses to oxycodone and cocaine.Neuropharmacology · 2025Article
- Dorsal CA3 overactivation mediates witnessing stress-induced recognition memory deficits in adolescent male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Revisiting sex as a biological variable in hypertension research.The Journal of clinical investigation · 2024Review
- Voluntary wheel running as a promising strategy to promote autonomic resilience to social stress in females: Vagal tone lies at the heart of the matter.Autonomic neuroscience : basic & clinical · 2024Review
- Maladaptive cardiac and behavioral reactivity to repeated vicarious stress exposure in socially bonded male prairie vole siblings.Autonomic neuroscience : basic & clinical · 2024Article
- Sex Differences in Stress Response: Classical Mechanisms and Beyond.Current neuropharmacology · 2024Article
- Learned Helplessness As a Potential Transdiagnostic Therapeutic Mechanism of Classic Psychedelics.Psychedelic medicine (New Rochelle, N.Y.) · 2023Review
- Estrogen receptor beta in the central amygdala regulates the deleterious behavioral and neuronal consequences of repeated social stress in female rats.Neurobiology of stress · 2023Article
- Site-Specific knockdown of microglia in the locus coeruleus regulates hypervigilant responses to social stress in female rats.Brain, behavior, and immunity · 2023Article
- ChAT::Cre transgenic rats show sex-dependent altered fear behaviors, ultrasonic vocalizations and cholinergic marker expression.Genes, brain, and behavior · 2023Article
- Stress- and drug-induced neuroimmune signaling as a therapeutic target for comorbid anxiety and substance use disorders.Pharmacology & therapeutics · 2022Review
- Sex differences in autonomic responses to stress: implications for cardiometabolic physiology.American journal of physiology. Endocrinology and metabolism · 2022Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWomen are at greater risk than men of developing depression and comorbid disorders such as cardiovascular disease. This enhanced risk begins at puberty and ends following menopause, suggesting a role for ovarian hormones in this sensitivity. Here we used a model of psychosocial witness stress in female rats to determine the stress-induced neurobiological adaptations that underlie stress susceptibility in an ovarian hormone-dependent manner.
methodsIntact or ovariectomized (OVX) female rats were exposed to five daily 15-minute witness-stress exposures. Witness-stress-evoked burying, behavioral despair, and anhedonia were measured. Cardiovascular telemetry was combined with plasma measurements of inflammation, epinephrine, and corticosterone as indices of cardiovascular dysfunction. Finally, levels of interleukin-1β and corticotropin-releasing factor were assessed in the central amygdala.
resultsWitness stress produced anxiety-like burying, depressive-like anhedonia, and behavioral despair selectively in intact female rats, which was associated with enhanced sympathetic responses during stress, including increased blood pressure, heart rate, and arrhythmias. Moreover, intact female rats exhibited increases in 12-hour resting systolic pressure and heart rate and reductions in heart rate variability. Notably, OVX female rats remained resilient. Moreover, intact, but not OVX, female rats exposed to witness stress exhibited a sensitized cytokine and epinephrine response to stress and distinct increases in levels of corticotropin-releasing factor and interleukin-1β in the central amygdala.
conclusionsTogether these data suggest that ovarian hormones play a critical role in the behavioral, inflammatory, and cardiovascular susceptibility to social stress in female rats and reveal putative systems that are sensitized to stress in an ovarian hormone-dependent manner.
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