ArticleNeurobiology of learning and memory2018
Neural measures associated with configural threat acquisition.
Article in Neurobiology of learning and memory, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neural correlates of uncertainty processing: meta-analysis of fMRI studies.Frontiers in neuroscience · 2025Pooled it
- The impact of doxycycline on human contextual fear memory.Psychopharmacology · 2024Trial
- Attenuating human fear memory retention with minocycline: a randomized placebo-controlled trial.Translational psychiatry · 2024Trial
- A prospective study of pre-trauma fear learning and extinction as risk factors for posttraumatic stress disorder.Journal of mood and anxiety disorders · 2025Article
- Integrating and fragmenting memories under stress and alcohol.Neurobiology of stress · 2024Article
- Surviving with story characters: What do we remember?Memory & cognition · 2023Article
- Measuring human context fear conditioning and retention after consolidation.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Elemental and configural threat learning bias extinction generalization.Neurobiology of learning and memory · 2021Article
- Generalization of Conditioned Contextual Anxiety and the Modulatory Effects of Anxiety Sensitivity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Article
- Characterizing the neural circuitry associated with configural threat learning.Brain research · 2019Article
- Contingency awareness as a prerequisite for differential contextual fear conditioning.Cognitive, affective & behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Contextual threat learning reflects two often competing processes: configural and elemental learning. Configural threat learning is a hippocampal-dependent process of forming a conjunctive representation of a context through binding of several multi-modal elements. In contrast, elemental threat-learning is governed by the amygdala and involves forming associative relationships between individual features within the context. Contextual learning tasks in humans however, rarely probe if a learned fear response is truly due to configural learning vs. simple elemental associations. The aim of the current study was to probe both constructs separately to enable a more refined interpretation of configural vs. elemental threat learning performance and mediating circuits. Subjects (n = 25) performed both a novel feature-identical contextual threat conditioning task and a discrete cue threat acquisition task while undergoing functional magnetic resonance imaging. Results demonstrated increased hippocampus activity for the threat configuration compared to the safe configuration. This pattern was not observed in the amygdala. In contrast, elemental threat learning was associated with increased amygdala, but not hippocampus activity. Whole-brain analyses revealed that both configural and elemental threat acquisition share neural circuitry related to fear expression. These results provide support for the importance of the hippocampus specifically in configural threat acquisition and fear expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.