ArticleArthritis research & therapy2018
Pain sensitivity at rest and during muscle contraction in persons with rheumatoid arthritis: a substudy within the Physical Activity in Rheumatoid Arthritis 2010 study.
Article in Arthritis research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 32 citations in OpenAlex.
- Effects of Acupuncture-Combined Tuina on Patients With Knee Osteoarthritis: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2026Trial
- Long-term, health-enhancing physical activity is associated with reduction of pain but not pain sensitivity or improved exercise-induced hypoalgesia in persons with rheumatoid arthritis.Arthritis research & therapy · 2018Trial
- High-definition transcranial direct current stimulation enhances exercise-induced hypoalgesia in patients with chronic low back pain.iScience · 2026Article
- Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain.Arthritis research & therapy · 2024Article
- Effect of Motor Imagery on Corticomotor Excitability and Pain Status in Rheumatoid Arthritis Patients.Cureus · 2023Article
- Combined Static Stretching and Electrical Muscle Stimulation Induce Greater Changes in Range of Motion, Passive Torque, and Tendon Displacement Compared with Static Stretching.Sports (Basel, Switzerland) · 2023Article
- Further evaluation of inflammatory and non-inflammatory aspects of pain in rheumatoid arthritis patients.Rheumatology advances in practice · 2023Article
- Acute effects of exercise on pain symptoms, clinical inflammatory markers and inflammatory cytokines in people with rheumatoid arthritis: a systematic literature review.Therapeutic advances in musculoskeletal disease · 2022Review
- Pain sensitivity in young adults with juvenile idiopathic arthritis: a quantitative sensory testing study.Arthritis research & therapy · 2020Article
- Exercise-induced pain threshold modulation in healthy subjects: a systematic review and meta-analysis.Principles and practice of clinical research (2015) · 2020Article
- Association of Pain Centralization and Patient-Reported Pain in Active Rheumatoid Arthritis.Arthritis care & research · 2020Article
- The effects of a 15-week physical exercise intervention on pain modulation in fibromyalgia: Increased pain-related processing within the cortico-striatal- occipital networks, but no improvement of exercise-induced hypoalgesia.Neurobiology of pain (Cambridge, Mass.)Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to explore pressure pain sensitivity and the function of segmental and plurisegmental exercise-induced hypoalgesia (EIH) in persons with rheumatoid arthritis (RA) compared with healthy control subjects (HC).
methodsForty-six participants with RA (43 female, 3 male) and 20 HC (16 female, 4 male) participated in the study. Pressure pain thresholds, suprathreshold pressure pain at rest, and segmental and plurisegmental EIH during standardised submaximal contractions were assessed by algometry. Assessments of EIH were made by performing algometry alternately at the contracting (30% of the individual maximum) right m. quadriceps and the resting left m. deltoideus.
resultsParticipants with RA had higher sensitivity to pressure pain (RA, 318 kPa; HC, 487 kPa; p < 0.001), suprathreshold pressure pain 4/10 (RA, 433 kPa; HC, 638 kPa; p = 0.001) and suprathreshold pressure pain 7/10 (RA, 620 kPa; HC, 851 kPa; p = 0.002) than HC. Segmental EIH (RA, 0.99 vs 1.27; p < 0.001; HC, 0.89 vs 1.10; p = 0.016) and plurisegmental EIH (RA, 0.95 vs 1.36; p < 0.001; HC, 0.87 vs 1.31; p < 0.001) increased significantly during static muscle contraction in both groups alike (p > 0.05).
conclusionsOur results indicate a generally increased pain sensitivity but normal function of EIH among persons with RA and offer one possible explanation for pain reduction observed in this group of patients following clinical exercise programmes.
trial registrationISRCTN registry, ISRCTN25539102 . Retrospectively registered on 4 March 2011.
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