Evidence map›Paper›PMID 29544513›Full record

ArticleJournal of neuroinflammation2018

Neonatal hyperglycemia induces CXCL10/CXCR3 signaling and microglial activation and impairs long-term synaptogenesis in the hippocampus and alters behavior in rats.

Katherine M Satrom, Kathleen Ennis, Brian M Sweis, Tatyana M Matveeva, Jun Chen, Leif Hanson, Akhil Maheshwari, Raghavendra Rao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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  19. Cerebral Effects of Neonatal Dysglycemia.Clinics in perinatology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Katherine M SatromDivision of Neonatology, Department of Pediatrics, University of Minnesota, PWB 420 Delaware St SE, Minneapolis, MN, 55455, USA. ksatrom@umn.edu.ORCID http://orcid.org/0000-0003-0893-3641
Kathleen EnnisDivision of Neonatology, Department of Pediatrics, University of Minnesota, PWB 420 Delaware St SE, Minneapolis, MN, 55455, USA.
Brian M SweisDepartment of Neuroscience, University of Minnesota, Jackson Hall, 321 Church St SE, Minneapolis, MN, USA.
Tatyana M MatveevaDepartment of Psychology, University of Minnesota, Elliot Hall, 75 E River Rd, Minneapolis, MN, USA.
Jun ChenDivision of Neonatology, Department of Pediatrics, University of Minnesota, PWB 420 Delaware St SE, Minneapolis, MN, 55455, USA.
Leif HansonDivision of Neonatology, Department of Pediatrics, University of Minnesota, PWB 420 Delaware St SE, Minneapolis, MN, 55455, USA.
Akhil MaheshwariDepartment of Pediatrics, Division of Neonatology, University of South Florida, Tampa General Cir, Suite HMT 450.19, Tampa, Florida, 33606, USA.
Raghavendra RaoDivision of Neonatology, Department of Pediatrics, University of Minnesota, PWB 420 Delaware St SE, Minneapolis, MN, 55455, USA.
University of Minnesota · USUniversity of South Florida · US

Funding

PREDOCTORAL TRAINING OF NEUROSCIENTISTST32GM008471 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI EBNER, TIMOTHY J · 1993 to 2017
$4.9M
Optogenetic modulation of decision-making circuitry in mouse models of addictionF30DA043326 · NIDA · UNIVERSITY OF MINNESOTA · PI SWEIS, BRIAN MUSA · 2017 to 2020
$139k
Vikings Children's Fund (US) UMF0015965
6 · The paper itself

Abstract

backgroundHyperglycemia is common in extremely low gestational age newborns (ELGAN) and is associated with increased mortality and morbidity, including abnormal neurodevelopment. Hippocampus-mediated cognitive deficits are common in this population, but the specific effects of hyperglycemia on the developing hippocampus are not known.

methodsThe objective of this study was to determine the acute and long-term effects of hyperglycemia on the developing hippocampus in neonatal rats using a streptozotocin (STZ)-induced model of hyperglycemia. STZ was injected on postnatal day (P) 2, and littermates in the control group were injected with an equivalent volume of citrate buffer. The acute effects of hyperglycemia on markers of oxidative stress, inflammatory cytokines, microglial activation, and reactive astrocytosis in the hippocampus were determined in the brain tissue collected on P6. The long-term effects on hippocampus-mediated behavior and hippocampal dendrite structure were determined on P90.

resultsOn P6, the transcript and protein expression of markers of oxidative stress and inflammatory cytokines, including the CXCL10/CXCR3 pathway, were upregulated in the hyperglycemia group. Histological evaluation revealed microglial activation and astrocytosis. The long-term assessment on P90 demonstrated abnormal performance in Barnes maze neurobehavioral testing and altered dendrite structure in the hippocampus of formerly hyperglycemic rats.

conclusionsNeonatal hyperglycemia induces CXCL10/CXCR3 signaling, microglial activation, and astrocytosis in the rat hippocampus and alters long-term synaptogenesis and behavior. These results may explain the hippocampus-specific cognitive deficits common in ELGAN who experience neonatal hyperglycemia.

Indexed as

Age FactorsAnimalsAnimals, NewbornAntibiotics, AntineoplasticCD11 AntigensChemokine CXCL10Developmental DisabilitiesDisks Large Homolog 4 ProteinEncephalitisFemaleHippocampusHyperglycemiaMaleMaze LearningMicrogliaMicrotubule-Associated ProteinsAntibiotics, AntineoplasticCD11 AntigensChemokine CXCL10Cxcr3 protein, ratDisks Large Homolog 4 ProteinDlg4 protein, ratMicrotubule-Associated ProteinsReceptors, CXCR3StreptozocinBlood glucoseELGANHippocampusHyperglycemiaInflammationNeurodevelopmentOxidative stressPrematurity

Identifiers

PMID29544513
PMCPMC5856387
OpenAlexW2792502988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.