ArticleMalaria journal2018
Insecticide resistance in Anopheles arabiensis populations from Dakar and its suburbs: role of target site and metabolic resistance mechanisms.
Article in Malaria journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 31 citations in OpenAlex.
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- Bionomics and distribution of malaria vectors in Kisumu city, Western Kenya: Implications for urban malaria transmission.Research square · 2024Article
- Predicting the age of fieldScience advances · 2024Article
- Differential insecticide resistance inHeliyon · 2023Article
- Estimating malaria transmission risk through surveillance of human-vector interactions in northern Ghana.Parasites & vectors · 2023Article
- Characterizing pyrethroid resistance and mechanisms inCurrent research in parasitology & vector-borne diseases · 2023Article
- First detection of the malaria vector Anopheles arabiensis in Côte d'Ivoire: urbanization in question.Malaria journal · 2022Article
- Evolution of the Pyrethroids Target-Site Resistance Mechanisms in Senegal: Early Stage of theGenes · 2021Article
- Multiple Resistance Mechanisms to Pyrethroids Insecticides in Anopheles gambiae sensu lato Population From Mali, West Africa.The Journal of infectious diseases · 2021Article
- Dynamic changes of transcriptome of fifth-instar3 Biotech · 2021Article
- Biochemical Mechanism of Insecticide Resistance in Malaria Vector,Iranian journal of public health · 2021Article
- Insecticide Resistance Profiling ofGenes · 2020Article
- Modelling and mapping the intra-urban spatial distribution of Plasmodium falciparum parasite rate using very-high-resolution satellite derived indicators.International journal of health geographics · 2020Article
- Status of insecticide resistance in Anopheles gambiae (s.l.) of The Gambia.Parasites & vectors · 2019Article
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrban malaria is an increasing concern in most of the sub-Saharan Africa countries. In Dakar, the capital city of Senegal, the malaria epidemiology has been complicated by recurrent flooding since 2005. The main vector control measure for malaria prevention in Dakar is the community use of long-lasting insecticide-treated nets. However, the increase of insecticide resistance reported in this area needs to be better understood for suitable resistance management. This study reports the situation of insecticide resistance and underlying mechanisms in Anopheles arabiensis populations from Dakar and its suburbs.
resultsAll the populations tested showed resistance to almost all insecticides except organophosphates families, which remain the only lethal molecules. Piperonil butoxide (PBO) and ethacrinic acid (EA) the two synergists used, have respectively and significantly restored the susceptibility to DDT and permethrin of Anopheles population. Molecular identification of specimens revealed the presence of An. arabiensis only. Kdr genotyping showed the presence of the L1014F mutation (kdr-West) as well as L1014S (kdr-East). This L1014S mutation was found at very high frequencies (89.53%) in almost all districts surveyed, and in association with the L1014F (10.24%).
conclusionResults showed the contribution of both target-site and metabolic mechanisms in conferring pyrethroid resistance to An. arabiensis from the flooded areas of Dakar suburbs. These data, although preliminary, stress the need for close monitoring of the urban An. arabiensis populations for a suitable insecticide resistance management system to preserve core insecticide-based vector control tools in this flooded area.
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