Evidence map›Paper›PMID 29544490›Full record

ArticleBMC complementary and alternative medicine2018

The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins.

Alain N'guessan Yao, Mamadou Kamagaté, Augustin Kouao Amonkan, Philippe Chabert, Fidèle Kpahé, Camille Koffi, Mathieu N'goran Kouamé, Cyril Auger, Séraphin Kati-Coulibaly, Valérie Schini-Kerth and 1 more

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In one paragraph

Article in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Alain N'guessan YaoDepartment of Pharmacology, UFR-SMA, Félix Houphouët-Boigny University, 01 BP V 166 Abidjan 01, Abidjan, Côte d'Ivoire. yalain08@yahoo.fr.
Mamadou KamagatéDepartment of Pharmacology, UFR-SMA, Félix Houphouët-Boigny University, 01 BP V 166 Abidjan 01, Abidjan, Côte d'Ivoire.
Augustin Kouao AmonkanLaboratory of Nutrition and Pharmacology, UFR-Biosciences, Félix Houphouët-Boigny University, Abidjan, Côte d'Ivoire.
Philippe ChabertUMR CNRS 7213, Laboratory of Biophotonics and Pharmacology, Faculty of Pharmacy, University of Strasbourg, Illkirch, France.
Fidèle KpahéLaboratory of Nutrition and Pharmacology, UFR-Biosciences, Félix Houphouët-Boigny University, Abidjan, Côte d'Ivoire.
Camille KoffiDepartment of Pharmacology, UFR-SMA, Félix Houphouët-Boigny University, 01 BP V 166 Abidjan 01, Abidjan, Côte d'Ivoire.
Mathieu N'goran KouaméDepartment of Pharmacology, UFR-SMA, Félix Houphouët-Boigny University, 01 BP V 166 Abidjan 01, Abidjan, Côte d'Ivoire.
Cyril AugerUMR CNRS 7213, Laboratory of Biophotonics and Pharmacology, Faculty of Pharmacy, University of Strasbourg, Illkirch, France.
Séraphin Kati-CoulibalyLaboratory of Nutrition and Pharmacology, UFR-Biosciences, Félix Houphouët-Boigny University, Abidjan, Côte d'Ivoire.
Valérie Schini-KerthUMR CNRS 7213, Laboratory of Biophotonics and Pharmacology, Faculty of Pharmacy, University of Strasbourg, Illkirch, France.
Henri Die-KakouDepartment of Pharmacology, UFR-SMA, Félix Houphouët-Boigny University, 01 BP V 166 Abidjan 01, Abidjan, Côte d'Ivoire.
Université Nangui Abrogoua · CICentre National de la Recherche Scientifique · FRLaboratoire de Biophotonique et Pharmacologie · FRUniversité de Strasbourg · FR

Funding

Ministère de l'Enseignement Supérieur et de la Recherche Scientifique of Côte d'Ivoire Décision N° 436 du 11/09/2013Sercice de Coopération et d'Action Culturelle of French Embassy of Côte d'Ivoire Campus France N° 767294B and 796998H
6 · The paper itself

Abstract

backgroundPhyllanthus amarus (Schum & Thonn), a plant belonging to the family of Euphorbiaceae is used in Ivorian traditional medicine to treat cardiovascular disorders such as hypertension. However, although this plant has been described as a diuretic agent, the underlying mechanism remains unclear. Therefore, the aim of the present study was to investigate the mechanism action of diuretic effects of an ethanolic fraction of Phyllanthus amarus (EFPA) in rats.

methodsEffects of EFPA on urinary excretion were carried out for doses ranging from 5 to 80 mg/kg given by intraperitoneal injection (i.p.) and compared with that induced by furosemide (5 mg/kg) after 8 h. Thereafter, the diuretic activity of EFPA was also evaluated in the presence of indomethacin (5 mg/kg, i.p.) in order to determine the involvement of prostaglandins, after 24 h.

resultsBetween 5 and 80 mg/kg, EFPA induced a significant urinary excretion. The profile of urinary excretion showed that after 2 h, the highest dose of 80 mg/kg induced a urinary volumetric excretion (UVE), which was similar to that induced by furosemide. After 24 h, EFPA at 10 mg/kg increased significantly UVE, Na

conclusionAltogether, this study has shown that EFPA promotes a significant urinary excretion of water and Na

Indexed as

AnimalsChloridesDiureticsHumansHypertensionMalePhyllanthusPlant ExtractsProstaglandinsRatsRats, WistarSodiumChloridesDiureticsPlant ExtractsProstaglandinsSodiumDiuresisElectrolytesPhyllanthus amarusProstaglandins

Identifiers

PMID29544490
PMCPMC5856278
OpenAlexW2806487158

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.