Evidence map›Paper›PMID 29544244›Full record

ArticleJournal of the American Chemical Society2018

Nickel-Catalyzed Dearomative trans-1,2-Carboamination.

Lucas W Hernandez, Ulrich Klöckner, Jola Pospech, Lilian Hauss, David Sarlah

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Copper-Catalyzed Dearomative 1,2-Hydroamination.Angewandte Chemie (International ed. in English) · 2024
    Article
  6. Copper-Catalyzed DearomativeACS catalysis · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. π-Extended Rubrenes via Dearomative Annulative π-Extension Reaction.Journal of the American Chemical Society · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Visible-Light-Induced Dearomatizations.European journal of organic chemistry · 2020
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lucas W HernandezRoger Adams Laboratory, Department of Chemistry , University of Illinois , Urbana , Illinois 61801 , United States.ORCID 0000-0001-9530-0927
Ulrich KlöcknerRoger Adams Laboratory, Department of Chemistry , University of Illinois , Urbana , Illinois 61801 , United States.
Jola PospechRoger Adams Laboratory, Department of Chemistry , University of Illinois , Urbana , Illinois 61801 , United States.
Lilian HaussRoger Adams Laboratory, Department of Chemistry , University of Illinois , Urbana , Illinois 61801 , United States.
David SarlahRoger Adams Laboratory, Department of Chemistry , University of Illinois , Urbana , Illinois 61801 , United States.ORCID 0000-0002-8736-8953

Funding

Dearomative Functionalization with ArenophilesR01GM122891 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SARLAH, DAVID · 2017 to 2025
$3.1M
NIGMS NIH HHS R01 GM122891
6 · The paper itself

Abstract

We describe the development of an arenophile-mediated, nickel-catalyzed dearomative trans-1,2-carboamination protocol. A range of readily available aromatic compounds was converted to the corresponding dienes using Grignard reagents as nucleophiles. This strategy provided products with exclusive trans-selectivity and high enantioselectivity was observed in case of benzene and naphthalene. The utility of this methodology was showcased by controlled and stereoselective preparation of small, functionalized molecules.

Indexed as

AminationCatalysisMolecular StructureNickelStereoisomerismNickel

Identifiers

PMID29544244
PMCPMC5971658

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.