ArticlePsychoneuroendocrinology2018
Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors.
Article in Psychoneuroendocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Steroid 5α-reductases in the brain: From neurosteroidogenesis to therapeutic implications.Frontiers in neuroendocrinology · 2026Review
- OpenStride: an inexpensive, open-source force plate actometry system for quantification of rodent motor activity and behaviour.Scientific reports · 2026Article
- 5α-Reductase Isoenzymes: From Neurosteroid Biosynthesis to Neuropsychiatric Outcomes.NeuroSci · 2026Review
- Population Variation in Steroid Hormone-Related Gene Expression and Sexually Dimorphic Communication in the Electric Fish Apteronotus albifrons.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- Differential neuronal functions of LNX1 and LNX2 revealed by behavioural analysis in single and double knockout mice.Behavioral and brain functions : BBF · 2025Article
- A novel naïve Bayes approach to identifying grooming behaviors in the force-plate actometric platform.Journal of neuroscience methods · 2024Article
- Androgen receptor deficiency is associated with reduced aromatase expression in the ventromedial hypothalamus of male cichlids.Annals of the New York Academy of Sciences · 2024Article
- Overlapping representations of food and social stimuli in VTA dopamine neurons.bioRxiv : the preprint server for biology · 2023Article
- Peer Social Environment Impacts Behavior and Dopamine D1 Receptor Density in Prairie Voles (Microtus ochrogaster).Neuroscience · 2023Article
- Control of social status by sex steroids: insights from teleost fishes.Molecular psychology : brain, behavior, and society · 2023Article
- Allopregnanolone is required for prepulse inhibition deficits induced by DPsychoneuroendocrinology · 2019Article
- Androgens modulate chronic intermittent hypoxia effects on brain and behavior.Hormones and behavior · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The enzyme steroid 5α-reductase 2 (5αR2) catalyzes the conversion of testosterone into the potent androgen 5α-dihydrotestosterone. Previous investigations showed that 5αR2 is expressed in key brain areas for emotional and socio-affective reactivity, yet the role of this enzyme in behavioral regulation remains mostly unknown. Here, we profiled the behavioral characteristics of 5αR2 heterozygous (HZ) and knockout (KO) mice, as compared with their wild-type (WT) littermates. While male 5αR2 KO mice displayed no overt alterations in motoric, sensory, information-processing and anxiety-related behaviors, they exhibited deficits in neurobehavioral correlates of dominance (including aggression against intruders, mating, and tube dominance) as well as novelty-seeking and risk-taking responses. Furthermore, male 5αR2 KO mice exhibited reduced D
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.