Evidence map›Paper›PMID 29543984›Full record

Observational studyMuscle & nerve2018

Electrical impedance myography in facioscapulohumeral muscular dystrophy: A 1-year follow-up study.

Karlien Mul, Chad Heatwole, Katy Eichinger, Nuran Dilek, William B Martens, Baziel G M Van Engelen, Rabi Tawil, Jeffrey M Statland

Abstract readObservational Study
In one paragraph

Observational study in Muscle & nerve, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Current Therapeutic Approaches in FSHD.Journal of neuromuscular diseases · 2021
    Review
  12. Fibrogenesis inFrontiers in molecular neuroscience · 2020
    Review
  13. Electrical Impedance Methods in Neuromuscular Assessment: An Overview.Cold Spring Harbor perspectives in medicine · 2019
    Review
  14. Article
  15. Facioscapulohumeral Muscular Dystrophy: Update on Pathogenesis and Future Treatments.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Karlien MulDepartment of Neurology, University of Kansas Medical Center, 4330 Shawnee Mission Parkway, Suite 323 Fairway, Kansas, 66205, USA.
Chad HeatwoleDepartment of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
Katy EichingerDepartment of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
Nuran DilekDepartment of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
William B MartensDepartment of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
Baziel G M Van EngelenDepartment of Neurology, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Rabi TawilDepartment of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
Jeffrey M StatlandDepartment of Neurology, University of Kansas Medical Center, 4330 Shawnee Mission Parkway, Suite 323 Fairway, Kansas, 66205, USA.ORCID 0000-0003-0790-5315
University of Rochester Medical Center · USRadboud University Nijmegen · NLShawnee Mission Medical Center · US

Funding

UNIVERSITY OF ROCHESTER'S RESEARCH ASSOCIATE ORGANIZATIONUL1RR024160 · NCRR · UNIVERSITY OF ROCHESTER · PI PEARSON, THOMAS ARTHUR · 2006 to 2011
$38.7M
The Pathogenesis of Facioscapulohumeral Muscular DystrophyP01NS069539 · NINDS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TAWIL, RABI · 2010 to 2019
$12.3M
Clinical Trial Readiness to Solve Barriers to Drug Development in FSHDU01NS101944 · NINDS · UNIVERSITY OF ROCHESTER · PI STATLAND, JEFFREY, TAWIL, RABI · 2017 to 2022
$3.2M
Heartland Institute for Clinical and Translational ResearchKL2TR000119 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BAROHN, RICHARD J. · 2012 to 2015
$2.5M
Development of a Clinically Relevant Outcome Measure for FSHD Therapeutic TrialsU01AR065119 · NIAMS · UNIVERSITY OF ROCHESTER · PI HEATWOLE, CHAD RYDEL · 2013 to 2015
$509k
NCATS NIH HHS KL2 TR000119NCRR NIH HHS UL1 RR024160NIAMS NIH HHS U01 AR065119NINDS NIH HHS P01 NS069539NINDS NIH HHS U01 NS101944
6 · The paper itself

Abstract

introductionElectrical impedance myography (EIM) is a noninvasive technique for measuring muscle composition and a potential physiological biomarker for facioscapulohumeral muscular dystrophy (FSHD).

methodsThirty-two participants with genetically confirmed and clinically affected FSHD underwent EIM in 7 muscles bilaterally. Correlations between EIM and baseline clinical measures were used to select EIM variables of interest in FSHD, and EIM and clinical measures were followed for 1 year.

resultsThere were no significant changes in the EIM variables. Although 50-kHZ reactance correlated the strongest with clinical measures at baseline, the 50-211-kHZ phase ratio demonstrated lower within-subject 12-month variability, potentially offering sample size savings for FSHD clinical trial planning. DISCUSSION: EIM did not identify significant disease progression over 12 months. It is currently unclear whether this is because of limitations of the technology or the slow rate of disease progression in this cohort of FSHD patients over this period of time. Muscle Nerve 58: 213-218, 2018.

Indexed as

AdultAgedBiomarkersClinical Trials as TopicCohort StudiesDisease ProgressionElectromyographyFemaleFollow-Up StudiesHumansMaleMiddle AgedMuscle StrengthMuscular Dystrophy, FacioscapulohumeralNegative ResultsPredictive Value of TestsBiomarkersbiomarkerelectrical impedance myographyfacioscapulohumeral muscular dystrophymuscle compositionmuscular dystrophyoutcome measure

Identifiers

PMID29543984
PMCPMC6105423
OpenAlexW2790035913

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.