Evidence map›Paper›PMID 29543886›Full record

ArticlePloS one2018

Quantifying positional variation of retinal blood vessels in glaucoma.

Mengyu Wang, Qingying Jin, Hui Wang, Neda Baniasadi, Tobias Elze

Abstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mengyu WangSchepens Eye Research Institute, Harvard Medical School, Boston, MA, United States of America.
Qingying JinSchepens Eye Research Institute, Harvard Medical School, Boston, MA, United States of America.
Hui WangSchepens Eye Research Institute, Harvard Medical School, Boston, MA, United States of America.
Neda BaniasadiSchepens Eye Research Institute, Harvard Medical School, Boston, MA, United States of America.
Tobias ElzeSchepens Eye Research Institute, Harvard Medical School, Boston, MA, United States of America.ORCID 0000-0002-2032-0496

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the relationship between major retinal blood vessel (BV) positions and glaucoma parameters based on pairs of Cirrus optical coherence tomography scans and Humphrey visual fields of 445 eyes from 445 glaucoma patients in our cross-sectional study. A trained observer marked the major superior and inferior temporal BV (artery and vein) positions on four concentric circles around the optic disc. Analysis of variance was performed to analyze the group differences of BV positions related to the factors of radius, BV type, myopia status and glaucoma stage. Subsequent t-tests were implemented to further study the effect of glaucoma stage on BV positions. The radial variations of BV positions were correlated to mean deviation and circumpapillary retinal nerve fiber layer thickness (cpRNFLT). We found significant main effects of BV type, radius and myopia status for superior and inferior BV positions and of glaucoma stage for superior BV positions (all p≤0.006) with significant superior artery nasalization in advanced compared to mild glaucoma on the two smallest circles (subsequent t-tests, p<0.05). In addition, MD (r = -0.10, p = 0.04) and cpRNFLT (r = -0.12, p = 0.02) were significantly correlated to the angle difference of superior arteries between the innermost and outermost circles. In conclusion, we demonstrated that peripapillary superior artery positions are significantly nasalized for advanced glaucoma.

Indexed as

AgedCross-Sectional StudiesFemaleGlaucomaHumansMaleMiddle AgedOptic DiskRetrospective StudiesTomography, Optical CoherenceVisual Field Tests

Identifiers

PMID29543886
PMCPMC5854294

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.