ArticlePloS one2018
A modular, open-source, slide-scanning microscope for diagnostic applications in resource-constrained settings.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- "UDE DIATOMS in the Wild 2024": a new image dataset of freshwater diatoms for training deep learning models.GigaScience · 2024Article
- Automating parasite egg detection: insights from the first AI-KFM challenge.Frontiers in artificial intelligence · 2024Article
- Article
- PiRamid: A compact Raspberry Pi imaging box to automate small-scale time-lapse digital analysis, suitable for laboratory and field use.HardwareX · 2022Article
- A review on low-cost microscopes for Open Science.Microscopy research and technique · 2022Review
- Affordable artificial intelligence-based digital pathology for neglected tropical diseases: A proof-of-concept for the detection of soil-transmitted helminths and Schistosoma mansoni eggs in Kato-Katz stool thick smears.PLoS neglected tropical diseases · 2022Article
- Handheld and Cost-Effective Fourier Lightfield Microscope.Sensors (Basel, Switzerland) · 2022Article
- Quantitative Imaging of Bacteriophage Amplification for Rapid Detection of Bacteria in Model Foods.Frontiers in microbiology · 2022Article
- Article
- Optical mesoscopy, machine learning, and computational microscopy enable high information content diagnostic imaging of blood films.The Journal of pathology · 2021Article
- The Kubic FLOTAC microscope (KFM): a new compact digital microscope for helminth egg counts.Parasitology · 2021Article
- Contemporary Whole Slide Imaging Devices and Their Applications within the Modern Pathology Department: A Selected Hardware Review.Journal of pathology informatics · 2021Review
- Nanometer precise red blood cell sizing using a cost-effective quantitative dark field imaging system.Biomedical optics express · 2020Article
- Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper we report the development of a cost-effective, modular, open source, and fully automated slide-scanning microscope, composed entirely of easily available off-the-shelf parts, and capable of bright field and fluorescence modes. The automated X-Y stage is composed of two low-cost micrometer stages coupled to stepper motors operated in open-loop mode. The microscope is composed of a low-cost CMOS sensor and low-cost board lenses placed in a 4f configuration. The system has approximately 1 micron resolution, limited by the f/# of available board lenses. The microscope is compact, measuring just 25×25×30 cm, and has an absolute positioning accuracy of ±1 μm in the X and Y directions. A Z-stage enables autofocusing and imaging over large fields of view even on non-planar samples, and custom software enables automatic determination of sample boundaries and image mosaicking. We demonstrate the utility of our device through imaging of fluorescent- and transmission-dye stained blood and fecal smears containing human and animal parasites, as well as several prepared tissue samples. These results demonstrate image quality comparable to high-end commercial microscopes at a cost of less than US$400 for a bright-field system, with an extra US$100 needed for the fluorescence module.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.