ArticleSexually transmitted diseases2018
Use of National Syphilis Surveillance Data to Develop a Congenital Syphilis Prevention Cascade and Estimate the Number of Potential Congenital Syphilis Cases Averted.
Article in Sexually transmitted diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Factors influencing adult and adolescent completion of treatment for late syphilis: a mixed methods systematic review.Bulletin of the World Health Organization · 2025Pooled it
- Gaps in Syphilis Screening Among Pregnant Women in North Carolina.Sexually transmitted diseases · 2026Article
- Characteristics Associated With Breakthrough Congenital Syphilis in Florida and Arizona, 2018-2022.Sexually transmitted diseases · 2026Article
- State-of-the-Art Review: Congenital Syphilis in the Modern Era: Current Strategies and Future Directions.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Review
- Article
- A Public Health Scourge: The Recent Surge of an Ancient Disease.Case reports in pathology · 2026Article
- Article
- Syphilis in pregnancy: A practical guide for prenatal care providers.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- Sociodemographic and clinical characteristics associated with maternal and congenital syphilis - A prospective study in Peru.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024Article
- Gaps in the prevention of mother-to-child transmission of syphilis: a review of reported cases, South Africa, January 2020-June 2022.Journal of tropical pediatrics · 2024Article
- Vital Signs: Missed Opportunities for Preventing Congenital Syphilis - United States, 2022.MMWR. Morbidity and mortality weekly report · 2023Article
- Risk Factors Associated with Congenital Syphilis, Georgia, 2008-2015.Infectious diseases in obstetrics and gynecology · 2023Observational
- Observational
- Gaps in the congenital syphilis prevention cascade: qualitative findings from Kern County, California.BMC infectious diseases · 2022Article
- Spatiotemporal dynamics of syphilis in pregnant women and congenital syphilis in the state of São Paulo, Brazil.Scientific reports · 2022Article
- Factors associated with inadequate treatment of syphilis during pregnancy: an integrative review.Revista brasileira de enfermagem · 2022Review
- Syphilis testing adherence among women with livebirth deliveries: Indianapolis 2014-2016.BMC pregnancy and childbirth · 2021Article
- Assessing the effects of disasters and their aftermath on pregnancy and infant outcomes: A conceptual model.International journal of disaster risk reduction : IJDRR · 2021Article
- Congenital syphilis with hydrops fetalis: report of four cases in a general referral hospital in Bogota, Colombia between 2016- 2020Revista colombiana de obstetricia y ginecologia · 2021Review
- Congenital syphilis in Argentina: Experience in a pediatric hospital.PLoS neglected tropical diseases · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRecent increases in reported congenital syphilis have led to an urgent need to identify interventions that will have the greatest impact on congenital syphilis prevention. We sought to create a congenital syphilis prevention cascade using national syphilis surveillance data to (1) estimate the proportion of potential congenital syphilis cases averted with current prevention efforts and (2) develop a classification framework to better describe why reported cases were not averted.
methodsWe reviewed national syphilis and congenital syphilis case report data from 2016, including pregnancy status of all reported female syphilis cases and data on prenatal care, testing, and treatment status of mothers of reported congenital syphilis cases to derive estimates of the proportion of pregnant women with syphilis who received prenatal care, syphilis testing, and adequate syphilis treatment at least 30 days before delivery, as well as the proportion of potential congenital syphilis cases averted.
resultsAmong the 2508 pregnant women who were reported to have syphilis, an estimated 88.0% received prenatal care at least 30 days before delivery, 89.4% were tested for syphilis at least 30 days before delivery, and 76.9% received an adequate treatment regimen that began at least 30 days before delivery. Overall, an estimated 1928 (75.0%) potential congenital syphilis cases in the United States were successfully averted. Among states that reported at least 10 syphilis cases among pregnant women, the estimated proportion of potential congenital syphilis cases averted ranged from 55.0% to 92.3%.
conclusionsAlthough the majority of potential congenital syphilis cases in the United States were averted in 2016, there was substantial geographic variation, and significant gaps in delivering timely prenatal care, syphilis testing, and adequate treatment to pregnant women with syphilis were identified. The congenital syphilis prevention cascade is a useful tool to quantify programmatic successes and identify where improvements are needed.
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