Evidence map›Paper›PMID 29543376›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2018

Lubricant use during intercourse and time to pregnancy: a prospective cohort study.

K A McInerney, K A Hahn, E E Hatch, E M Mikkelsen, A Z Steiner, K J Rothman, H T Sørensen, T M Snerum, L A Wise

Abstract read
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

K A McInerneyDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
K A HahnDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
E E HatchDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
E M MikkelsenDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
A Z SteinerDepartment of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA.
K J RothmanDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
H T SørensenDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
T M SnerumPediatric Department, Regional Hospital Viborg, Viborg, Denmark.
L A WiseDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Funding

An internet-based preconception cohort study in North America and DenmarkR01HD086742 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAUREN A WISE · 2016 to 2026
$6.7M
An internet based prospective study of time to pregnancyR01HD060680 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HATCH, ELIZABETH E · 2010 to 2014
$2.6M
BURPPE:BU Reproductive, Perinatal, and Pediatric Epidemiology Training ProgramT32HD052458 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WERLER, MARTHA M. · 2007 to 2016
$2.0M
A Pilot Study Of Internet Recruitment and follow-up among Reproductive Age WomenR21HD050264 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HATCH, ELIZABETH E · 2006 to 2007
$399k
Feasibility of an internet-based study of time-to-pregnancy in the United StatesR21HD072326 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WISE, LAUREN A · 2013 to 2014
$337k
Lifestyle and psychosocial determinants of male subfertility: a prospective studyR03HD090315 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WISE, LAUREN A · 2017 to 2018
$165k
Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNICHD NIH HHS R01 HD060680NICHD NIH HHS R01 HD086742NICHD NIH HHS R03 HD090315NICHD NIH HHS R21 HD050264NICHD NIH HHS R21 HD072326NICHD NIH HHS T32 HD052458NIH HHS R01-HD086742NIH HHS R03-HD090315NIH HHS R21-HD072326NIH HHS T32-HD052458
6 · The paper itself

Abstract

objectiveTo assess the extent to which lubricant use during intercourse is associated with time to pregnancy (TTP).

designProspective cohort study.

settingDenmark and North America. POPULATION: A total of 6467 women aged 18-49 years who were not using contraception or fertility treatment.

methodsWe pooled data from two continuing prospective cohort studies of pregnancy planners in Denmark (2011-2017) and North America (2013-2017). Female participants completed bimonthly questionnaires for 12 months or until they reported pregnancy. After restricting the study to women without a history of infertility who had been trying to conceive for six or fewer cycles at enrollment, 6467 women were retained for analysis. Self-reported lubricant use was categorised as water-based/not pH balanced, water-based/pH balanced 'fertility friendly', silicone-based, oil-based, or a combination of these. We used proportional probability models to calculate fecundability ratios (FRs) and 95% confidence intervals (95% CIs) for the association between lubricant use and fecundability, after adjusting for cohort and sociodemographic and lifestyle factors.

main outcome measureFecundability.

resultsAt baseline, 17.5% of participants reported the use of lubricants, most commonly water-based/not pH balanced (11.4%). Compared with non-use of lubricants, FRs were 1.02 (95% CI 0.93-1.11) for water-based/not pH-balanced lubricant use, 1.01 (95% CI 0.86-1.18) for water-based/pH balanced 'fertility friendly' lubricant use, 1.23 (95% CI 0.94-1.61) for oil-based lubricant use, and 1.27 (95% CI 0.93-1.73) for silicone-based lubricant use. Associations between oil-based lubricant use and fecundability were inconsistent across subgroups of study cohort, age, parity, and intercourse frequency.

conclusionsLubricant use was not associated with reduced fecundability in the preconception cohorts of pregnancy planners studied. TWEETABLE ABSTRACT: Lubricant use during intercourse was not associated with time to pregnancy in a study of pregnancy planners.

Indexed as

CoitusInfertility, FemaleLubricantsTime-to-PregnancyAdolescentAdultCohort StudiesFemaleHumansMiddle AgedPregnancyProspective StudiesSurveys and QuestionnairesYoung AdultLubricantsCohortepidemiologyfecundabilityfertilitylubricant

Identifiers

PMID29543376
PMCPMC6139089

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.