ArticleMolecular reproduction and development2018
Volumetric imaging of the developing prepubertal mouse uterine epithelium using light sheet microscopy.
Article in Molecular reproduction and development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- ERBB2 establishes the timing of progesterone priming required for uterine receptivity.bioRxiv : the preprint server for biology · 2026Article
- Endometrial cells with high ALDH activity contribute to uterine development and regeneration.eLife · 2026Article
- Generation and Characterization of a Rdh1-iCre Line to Study Uterine Glandular Biology.Genesis (New York, N.Y. : 2000) · 2026Article
- A transient epithelial plasticity state defines the developmental window for uterine gland specification.bioRxiv : the preprint server for biology · 2026Article
- Endometrial cells with high ALDH activity contribute to uterine development and regeneration.Research square · 2026Article
- Uterine collagen deposition fluctuates throughout the estrous cycle and provides a scaffold for gland visualization via theiScience · 2025Article
- A Cxcl15 Cre Recombinase Mouse Model Useful to Study Gland Development in the Uterus.Genesis (New York, N.Y. : 2000) · 2025Article
- Uterine organoids reveal insights into epithelial specification and plasticity in development and disease.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- 3D visualization of uterus and ovary: tissue clearing techniques and biomedical applications.Frontiers in bioengineering and biotechnology · 2025Review
- Tissue clearing and imaging approaches for in toto analysis of the reproductive system†.Biology of reproduction · 2024Review
- Histopathological evaluation of infertility: Lessons from laboratory rodents.Histology and histopathology · 2024Review
- Murine uterine gland branching is necessary for gland function in implantation.Molecular human reproduction · 2024Article
- Single-cell insights into epithelial morphogenesis in the neonatal mouse uterus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Distinguish Characters of Luminal and Glandular Epithelium from Mouse Uterus Using a Novel Enzyme-Based Separation Method.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy.Developmental cell · 2023Article
- A re-appraisal of mesenchymal-epithelial transition (MET) in endometrial epithelial remodeling.Cell and tissue research · 2023Article
- Morphogenesis of the female reproductive tract along antero-posterior and dorso-ventral axes is dependent on Amhr2+ mesenchyme in mice†.Biology of reproduction · 2022Article
- BMP/SMAD1/5 Signaling in the Endometrial Epithelium Is Essential for Receptivity and Early Pregnancy.Endocrinology · 2022Article
- Chronic Estrus Disrupts Uterine Gland Development and Homeostasis.Endocrinology · 2022Article
- Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium.Nature communications · 2022Observational
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Endometrial or uterine glands secrete substances essential for uterine receptivity to the embryo, implantation, conceptus survival, and growth. Adenogenesis is the process of gland formation within the stroma of the uterus. In the mouse, uterine gland formation initiates at postnatal day (P) 5. Uterine gland morphology is poorly understood because it is primarily based on two-dimensional (2D) histology. To more fully describe uterine gland morphogenesis, we generated three-dimensional (3D) models of postnatal uterine glands from P0 to P21, based on volumetric imaging using light sheet microscopy. At birth (P0), there were no glands. At P8, we found bud- and teardrop-shaped epithelial invaginations. By P11, the forming glands were elongated epithelial tubes. By P21, the elongated tubes had a sinuous morphology. These morphologies are homogeneously distributed along the anterior-posterior axis of the uterus. To facilitate uterine gland analyses, we propose a novel 3D staging system of uterine gland morphology during development in the prepubertal mouse. We define five uterine gland stages: Stage 1: bud; Stage 2: teardrop; Stage 3: elongated; Stage 4: sinuous; and Stage 5: primary branches. This staging system provides a standardized key to assess and quantify prepubertal uterine gland morphology that can be used for studies of uterine gland development and pathology. In addition, our studies suggest that gland formation initiation occurs during P8 and P11. However, between P11 and P21 gland formation initiation stops and all glands elongate and become sinuous. We also found that the mesometrial epithelium develops a unique morphology we term the uterine rail.
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