SynthesisThe Cochrane database of systematic reviews2018
Oral vitamin B
Synthesis in The Cochrane database of systematic reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis.Irish journal of medical science · 2024Pooled it
- The role of vitamin B12 in viral infections: a comprehensive review of its relationship with the muscle-gut-brain axis and implications for SARS-CoV-2 infection.Nutrition reviews · 2022Pooled it
- Pooled it
- Trial
- Severe Methylmalonic Acidemia Precipitated by Dietary B12 Deficiency in Vegan Toddler.Pediatric reports · 2026Article
- Nitrous Oxide-Induced Pancytopenia and Peripheral Neuropathy From Chronic Whip-It™ Use: A Case Report.Cureus · 2026Article
- Vitamin BNutrients · 2026Review
- Vitamin BThe Cochrane database of systematic reviews · 2026Article
- Less Is More: A Physiological Dose of Vitamin B12 Enhances Neural Recovery Compared to a High Dose in an H₂O₂-Stressed SH-SY5Y Neural-Like Cell Model.Molecular neurobiology · 2026Article
- Vitamin B12 Deficiency in the Diagnostic Work-Up of Global Developmental Delay: A Treatable and Time-Sensitive Condition.Nutrients · 2026Review
- Rapid Restoration of Circulating Vitamin B12 Levels by Using Oral SucrosomialPharmaceutics · 2026Article
- B Vitamin Deficiencies and Associated Neuropathies.Current nutrition reports · 2026Review
- Intramuscular Cyanocobalamin Treatment in Patients with Corpus Atrophic Gastritis and Vitamin BNutrients · 2026Article
- Diagnosis and treatment of vitamin B12 deficiency in children.Frontiers in nutrition · 2026Review
- Revisiting the hematological manifestations of vitamin B12 deficiency.Frontiers in nutrition · 2026Review
- Vitamin B12 and Affective Disorders: A Focus on the Gut-Brain Axis.Alpha psychiatry · 2025Review
- Elevated serum cobalamin levels in childhood: a retrospective analysis.BMC pediatrics · 2025Article
- Vitamin B12 in Cancer Patients: Clinical Insights into Deficiency, Excess, Diagnosis, and Management.Nutrients · 2025Review
- Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Review
- Severe Pernicious Anemia: A Case Report.Cureus · 2025Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Update of
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin B
objectivesTo assess the effects of oral vitamin B SEARCH
methodsWe searched CENTRAL, MEDLINE, Embase, and LILACS, as well as the WHO ICTRP and ClinicalTrials.gov. The latest search date was 17 July 2017. We applied no language restrictions. We also contacted authors of relevant trials to enquire about other published or unpublished studies and ongoing trials. SELECTION CRITERIA: Randomised controlled trials (RCTs) comparing the effect of oral versus IM vitamin B DATA COLLECTION AND ANALYSIS: We used standard methodological procedures expected by Cochrane. Our primary outcomes were serum vitamin B MAIN
resultsThree RCTs met our inclusion criteria. The trials randomised 153 participants (74 participants to oral vitamin B AUTHORS'
conclusionsLow quality evidence shows oral and IM vitamin B
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.