ArticleAmerican journal of physiology. Lung cellular and molecular physiology2018
Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.
Article in American journal of physiology. Lung cellular and molecular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Polydatin alleviates sepsis‑induced acute lung injury via downregulation of Spi‑B.Biomedical reports · 2023Article
- Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection.Frontiers in immunology · 2023Article
- Comparable Impairment of Vascular Endothelial Function by a Wide Range of Electronic Nicotine Delivery Devices.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Article
- Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Cigarette Smoke Exposure and Acute Respiratory Distress Syndrome in Sepsis: Epidemiology, Clinical Features, and Biologic Markers.American journal of respiratory and critical care medicine · 2022Article
- Article
- CIGARETTE SMOKING INCREASES THE RISK OF ACUTE RESPIRATORY DISTRESS SYNDROME.Transactions of the American Clinical and Climatological Association · 2022Article
- Delayed angiopoietin-2 blockade reduces influenza-induced lung injury and improves survival in mice.Physiological reports · 2021Article
- Environmental Factors.Critical care clinics · 2021Review
- Inhibition of the lipoxin A4 and resolvin D1 receptor impairs host response to acute lung injury caused by pneumococcal pneumonia in mice.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Immunopathological features of air pollution and its impact on inflammatory airway diseases (IAD).The World Allergy Organization journal · 2020Review
- The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung.Intensive care medicine experimental · 2020Article
- Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care. NHLBI Working Group Report.American journal of respiratory and critical care medicine · 2020Article
- The ex vivo perfused human lung is resistant to injury by high-doseAmerican journal of physiology. Lung cellular and molecular physiology · 2020Article
- Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Article
- Effects of smoking on the lower respiratory tract microbiome in mice.Respiratory research · 2018Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Evidence is accumulating that exposure to cigarette smoke (CS) increases the risk of developing acute respiratory distress syndrome (ARDS). Streptococcus pneumoniae is the most common cause of bacterial pneumonia, which in turn is the leading cause of ARDS. Chronic smokers have increased rates of pneumococcal colonization and develop more severe pneumococcal pneumonia than nonsmokers; yet mechanistic connections between CS exposure, bacterial pneumonia, and ARDS pathogenesis remain relatively unexplored. We exposed mice to 3 wk of moderate whole body CS or air, followed by intranasal inoculation with an invasive serotype of S. pneumoniae. CS exposure alone caused no detectable lung injury or bronchoalveolar lavage (BAL) inflammation. During pneumococcal infection, CS-exposed mice had greater survival than air-exposed mice, in association with reduced systemic spread of bacteria from the lungs. However, when mice were treated with antibiotics after infection to improve clinical relevance, the survival benefit was lost, and CS-exposed mice had more pulmonary edema, increased numbers of BAL monocytes, and elevated monocyte and lymphocyte chemokines. CS-exposed antibiotic-treated mice also had higher serum surfactant protein D and angiopoietin-2, consistent with more severe lung epithelial and endothelial injury. The results indicate that acute CS exposure enhances the recruitment of immune cells to the lung during bacterial pneumonia, an effect that may provide microbiological benefit but simultaneously exposes the mice to more severe inflammatory lung injury. The inclusion of antibiotic treatment in preclinical studies of acute lung injury in bacterial pneumonia may enhance clinical relevance, particularly for future studies of current or emerging tobacco products.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.