ArticleThe European journal of general practice2018
Previous antibiotic exposure and antibiotic resistance of commensal Staphylococcus aureus in Spanish primary care.
Article in The European journal of general practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Bacterial infections and pathogenic situations: The case ofVirulence · 2025Review
- Staphylococcus aureus Biofilm Destabilization by Tween-80 and Lung Surfactants to Overcome Biofilm-Imposed Drug Resistance.Applied biochemistry and biotechnology · 2024Article
- Antimicrobial Therapy in Pediatric Sepsis: What Is the Best Strategy?Frontiers in pediatrics · 2022Review
- Antimicrobial stewardship in rural and remote primary health care: a narrative review.Antimicrobial resistance and infection control · 2021Review
- Nano-graphene oxide improved the antibacterial property of antisense yycG RNA on Staphylococcus aureus.Journal of orthopaedic surgery and research · 2019Article
- European primary care research and a national general practice research agenda.The European journal of general practice · 2019Article
- The Pathogenicity and Transcriptome Analysis of Methicillin-ResistantEvidence-based complementary and alternative medicine : eCAM · 2019Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCommensal flora of healthy people is becoming an important reservoir of resistant bacteria.
objectivesTo evaluate the relationship of previous antibiotic-dispensed and resistance pattern of strains of Staphylococcus aureus in primary care patients.
methodsA cross-sectional study was carried out in seven primary care centres in Catalonia, Spain, from October 2010 to May 2011, as part of the APRES (The appropriateness of prescribing antibiotics in primary care in Europe concerning antibiotic resistance) study. Outpatients aged 4 or more who did not present an infectious disease and had not taken antibiotic or had not been hospitalised in the previous 3 months were invited to participate. Nasal swabs were collected for S. aureus culture, and antimicrobial susceptibility testing was carried out. Antibiotics dispensed boxes in the previous 4 years were extracted from Information System for Research in Primary Care.
resultsA total of 4,001 nasal swabs were collected, and 3,969 were tested for identification, 765 S. aureus were tested for resistance. Resistance rates to penicillin, azithromycin and methicillin were 87.1%, 11.6% and 1.3%, respectively, and a total of 10 MRSA strains were isolated (1.3%). Penicillin-resistant staphylococci were statistically significantly associated with the previous number of packages of penicillin dispensed (OR, 1.18; 95% CI, 1.04-1.35).
conclusionAlthough no causal inference is possible, an association was observed between previous antibiotic dispensation and isolation of resistant organisms in community-dwelling individuals, mainly between packages of penicillin and penicillin-resistant staphylococci.
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