Evidence map›Paper›PMID 29542358›Full record

ArticleDrug delivery2018

Nasal delivery of H5N1 avian influenza vaccine formulated with GenJet™ or in vivo-jetPEI

Weiping Cao, Margarita Mishina, Samuel Amoah, Wadzanai P Mboko, Caitlin Bohannon, James McCoy, Suresh K Mittal, Shivaprakash Gangappa, Suryaprakash Sambhara

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Weiping Caoa Immunology and Pathogenesis Branch , National Center for Immunization and Respiratory Diseases , Atlanta , GA , USA.
Margarita Mishinaa Immunology and Pathogenesis Branch , National Center for Immunization and Respiratory Diseases , Atlanta , GA , USA.
Samuel Amoaha Immunology and Pathogenesis Branch , National Center for Immunization and Respiratory Diseases , Atlanta , GA , USA.
Wadzanai P Mbokod Department of Comparative Pathobiology , Purdue University , West Lafayette , IN , USA.
Caitlin Bohannona Immunology and Pathogenesis Branch , National Center for Immunization and Respiratory Diseases , Atlanta , GA , USA.
James McCoyf Department of Pathology and Laboratory Medicine , Emory University , Atlanta , GA , USA.
Suresh K Mittald Department of Comparative Pathobiology , Purdue University , West Lafayette , IN , USA.
Shivaprakash Gangappaa Immunology and Pathogenesis Branch , National Center for Immunization and Respiratory Diseases , Atlanta , GA , USA.
Suryaprakash Sambharaa Immunology and Pathogenesis Branch , National Center for Immunization and Respiratory Diseases , Atlanta , GA , USA.

Funding

Adenoviral Vector-based Pandemic Influenza VaccineR01AI059374 · NIAID · PURDUE UNIVERSITY WEST LAFAYETTE · PI SURESH K MITTAL · 2005 to 2026
$5.0M
NIAID NIH HHS R01 AI059374
6 · The paper itself

Abstract

Avian influenza virus infection is a serious public health threat and preventive vaccination is the most cost-effective public health intervention strategy. Unfortunately, currently available unadjuvanted avian influenza vaccines are poorly immunogenic and alternative vaccine formulations and delivery strategies are in urgent need to reduce the high risk of avian influenza pandemics. Cationic polymers have been widely used as vectors for gene delivery in vitro and in vivo. In this study, we formulated H5N1 influenza vaccines with GenJet™ or in vivo-jetPEI

Indexed as

Drug Delivery SystemsAdaptive ImmunityAdministration, IntranasalAnimalsAntibodies, ViralB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDrug CompoundingFemaleImmunity, CellularImmunogenicity, VaccineIndicators and ReagentsInfluenza A Virus, H5N1 SubtypeInfluenza in BirdsInfluenza VaccinesAntibodies, ViralIndicators and ReagentsInfluenza VaccinesVaccines, Syntheticadaptive immunityCationic polymersH5N1 vaccineinfluenzamouse modelprotective immunity

Identifiers

PMID29542358
PMCPMC6058713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.