Evidence map›Paper›PMID 29542219›Full record

ArticleTraffic (Copenhagen, Denmark)2018

The Sla1 adaptor-clathrin interaction regulates coat formation and progression of endocytosis.

Thomas O Tolsma, Lena M Cuevas, Santiago M Di Pietro

Open access · bronzeAbstract read
In one paragraph

Article in Traffic (Copenhagen, Denmark), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Thomas O TolsmaDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado.
Lena M CuevasDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado.
Santiago M Di PietroDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado.ORCID 0000-0002-3372-8757
Colorado State University · US

Funding

Molecular Mechanism of Platelet Dense Granule BiogenesisR01HL106186 · NHLBI · COLORADO STATE UNIVERSITY · PI DI PIETRO, SANTIAGO MAURO · 2012 to 2016
$1.9M
NHLBI NIH HHS R01 HL106186
6 · The paper itself

Abstract

Clathrin-mediated endocytosis is a fundamental transport pathway that depends on numerous protein-protein interactions. Testing the importance of the adaptor protein-clathrin interaction for coat formation and progression of endocytosis in vivo has been difficult due to experimental constrains. Here, we addressed this question using the yeast clathrin adaptor Sla1, which is unique in showing a cargo endocytosis defect upon substitution of 3 amino acids in its clathrin-binding motif (sla1

Indexed as

Actin-Related Protein 2-3 ComplexActinsAdaptor Proteins, Signal TransducingClathrinCytoskeletal ProteinsEndocytosisFungal ProteinsProtein BindingYeastsActin-Related Protein 2-3 ComplexActinsAdaptor Proteins, Signal TransducingClathrinCytoskeletal ProteinsFungal Proteinsadaptor proteinclathrinendocytic machineryendocytosisyeast

Identifiers

PMID29542219
PMCPMC5990253
OpenAlexW2790971222

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.