Evidence map›Paper›PMID 29542123›Full record

ArticleJournal of periodontology2018

The association of periodontal disease and cardiovascular disease risk: Results from the Hispanic Community Health Study/Study of Latinos.

Richard H Singer, Mark Stoutenberg, Daniel J Feaster, Jianwen Cai, WayWay M Hlaing, Lisa R Metsch, Christian R Salazar, Shirley M Beaver, Tracy L Finlayson, Gregory Talavera and 2 more

Abstract read
In one paragraph

Article in Journal of periodontology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Richard H SingerUniversity of Miami, Miller School of Medicine, Department of Public Health Sciences, Miami, FL.
Mark StoutenbergUniversity of Miami, Miller School of Medicine, Department of Public Health Sciences, Miami, FL.
Daniel J FeasterUniversity of Miami, Miller School of Medicine, Department of Public Health Sciences, Miami, FL.
Jianwen CaiUniversity of North Carolina, Gillings School of Global Public Health, Collaborate Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC.
WayWay M HlaingUniversity of Miami, Miller School of Medicine, Department of Public Health Sciences, Miami, FL.
Lisa R MetschColumbia University, Mailman School of Public Health, Department of Sociomedical Sciences, New York, NY.
Christian R SalazarAlbert Einstein College of Medicine, Department of Epidemiology and Population Health, New York, NY.
Shirley M BeaverUniversity of Illinois at Chicago College of Dentistry, Chicago, IL.
Tracy L FinlaysonSan Diego State University, Graduate School of Public Health, San Diego, CA.
Gregory TalaveraSan Diego State University, Graduate School of Public Health, San Diego, CA.
Marc D GellmanUniversity of Miami, Department of Psychology, Miami, FL.
Neil SchneidermanUniversity of Miami, Department of Psychology, Miami, FL.
University of Miami · USSan Diego State University · USAlbert Einstein College of Medicine · USColumbia University · USNova Southeastern University · USUniversity of Illinois Chicago · USUniversity of North Carolina at Chapel Hill · US

Funding

Thalassemia Clinical Research Network, CanadaU01HL065233 · NHLBI · UNIVERSITY HEALTH NETWORK · PI OLIVIERI, NANCY F · 2000 to 2009
$2.6M
GENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1R01HL065234 · NHLBI · VANDERBILT UNIVERSITY · PI MOORE, JASON H. · 2000 to 2004
$1.7M
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237
6 · The paper itself

Abstract

backgroundCurrent evidence suggests that periodontal disease (PD) is associated with a significant increased risk of atherosclerotic cardiovascular disease (CVD) independent of known confounders. PD is a chronic oral disease with significant variation in prevalence demonstrated among Hispanic/Latino subgroups. The purpose of this study was to investigate the associations between PD and CVD risk and variations with sex, age, and Hispanic/Latino background.

methodsThe sample included 7379 participants aged 30 to 74 years, from the Hispanic Community Health Study/Study of Latinos (2008 to 2011). We assessed CVD risk by the Framingham 10-year general CVD risk score (FGRS). PD severity classification was based on calibrated measurements of gingival recession and probing depth. Multivariable sequential linear models for complex sample design assessed FGRS by PD severity, Hispanic/Latino background, and covariates.

resultsThe prevalence of moderate and severe PD combined was 46%. For women and men with severe PD, the combined prevalence of moderate and high CVD risk was 44% and 85%, respectively. The FGRS observed for women (5.1% [95% CI: 4.1%, 6.0%], p < 0.001) and men 10.8% (95% CI [9.2%, 12.3%], p < 0.001) with severe PD were 56% and 134% greater than those without PD, respectively. Dominican women and men with moderate or severe PD, aged 60 to 69 years, exhibited the greatest CVD risks (FGRS = 15.1%, 95% CI [7.8%, 22.5%]) and (FGRS = 40.2%, 95% CI [30.2%, 50.3%]), respectively.

conclusionsModerate and severe PD were associated with significant CVD risk with marked sex disparity and heterogeneity by Hispanic/Latino background.

Indexed as

Cardiovascular DiseasesPeriodontal DiseasesAdultAgedCross-Sectional StudiesFemaleHispanic or LatinoHumansMaleMiddle AgedPrevalencePublic HealthRisk FactorsUnited Statescardiovascular diseasescross-sectional studiesepidemiologyHispanic Americansperiodontal diseasesrisk factor(s)

Identifiers

PMID29542123
PMCPMC6105526
OpenAlexW2907318515

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.