Evidence map›Paper›PMID 29542088›Full record

ReviewAdvances in experimental medicine and biology2018

Transgenic Techniques for Investigating Cell Biology During Development.

Christina D Cota

Abstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Christina D CotaSwarthmore College, Swarthmore, PA, USA. ccota1@swarthmore.edu.

Funding

Signaling pathways in early heart developmentR01HL091027 · NHLBI · UNIVERSITY OF ARIZONA · PI DAVIDSON, BRADLEY J · 2008 to 2012
$1.9M
Chordate heart gene networksR15HD080525 · NICHD · SWARTHMORE COLLEGE · PI DAVIDSON, BRADLEY J · 2014 to 2014
$421k
NHLBI NIH HHS R01 HL091027NICHD NIH HHS R15 HD080525NICHD NIH HHS R15 HD080525-01
6 · The paper itself

Abstract

Ascidians are increasingly being used as a system for investigating cell biology during development. The extreme genetic and cellular simplicity of ascidian embryos in combination with superior experimental tractability make this an ideal system for in vivo analysis of dynamic cellular processes. Transgenic approaches to cellular and sub-cellular analysis of ascidian development have begun to yield new insights into the mechanisms regulating developmental signaling and morphogenesis. This chapter focuses on the targeted expression of fusion proteins in ascidian embryos and how this technique is being deployed to garner new insights into the cell biology of development.

Indexed as

Gene Expression Regulation, DevelopmentalGene Transfer TechniquesAnimalsAnimals, Genetically ModifiedCell CycleCell MovementEmbryo, NonmammalianGenes, ReporterGenes, SyntheticLarvaLuminescent ProteinsNeural TubeOrgan SpecificityPromoter Regions, GeneticRecombinant Fusion ProteinsSignal TransductionLuminescent ProteinsRecombinant Fusion ProteinsAscidiansCardiac inductionCell cycle progressionCiona intestinalisCollective cell migrationFusion proteinsHalocynthia roretziPhallusia mammillataSpindle positioning

Identifiers

PMID29542088
PMCPMC6373173

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.