Evidence map›Paper›PMID 29542066›Full record

SynthesisEating and weight disorders : EWD2018

A systematic review of studies on the faecal microbiota in anorexia nervosa: future research may need to include microbiota from the small intestine.

Hanna Ferløv Schwensen, Carol Kan, Janet Treasure, Niels Høiby, Magnus Sjögren

Open access · greenAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Eating and weight disorders : EWD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. The Neurobiology of Eating Disorders.Child and adolescent psychiatric clinics of North America · 2019
    Review
  14. The microbiome and mental health: Hope or hype?Journal of psychiatry & neuroscience : JPN · 2019
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Hanna Ferløv SchwensenMental Health Center Ballerup, Ballerup, Denmark.ORCID http://orcid.org/0000-0002-0926-477X
Carol KanInstitute of Psychiatry, King's College London, London, UK.
Janet TreasureInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Niels HøibyDepartment Clinical Microbiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Magnus SjögrenMental Health Center Ballerup, Ballerup, Denmark. jan.magnus.sjoegren@regionh.dk.
King's College London · GBUniversity of Copenhagen · DKCenter for Clinical & Basic Research · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAnorexia nervosa (AN) is a poorly understood and often chronic condition. Deviations in the gut microbiota have been reported to influence the gut-brain axis in other disorders. Therefore, if present in AN, it may impact on symptoms and illness progression. A review of the gut microbiota studies in AN is presented.

methodA literature search on PubMed yielded 27 articles; 14 were selected and based on relevance, 9 articles were included. The findings were interpreted in the larger context of preclinical research and clinical observations.

results8 out of 9 included studies analysed microbiota from faeces samples, while the last analysed a protein in plasma produced by the gut. Two studies were longitudinal and included an intervention (i.e., weight restoration), five were cross-sectional, one was a case report, and the last was a case series consisting of three cases. Deviations in abundance, diversity, and microbial composition of the faecal microbiota in AN were found.

conclusionThere are currently only a few studies on the gut microbiota in AN, all done on faeces samples, and not all describe the microbiota at the species level extensively. The Archaeon Methanobrevibacter smithii was increased in participants with a BMI < 25 in one study and specifically in AN patients in three studies. Methanobrevibacter smithii may, if detected, be a benchmark biomarker for future studies. We propose that microbiota samples could also be collected from the small intestine, where a major exchange of nutrients takes place and where the microbiota may have a biological impact on AN.

Indexed as

Gastrointestinal MicrobiomeAnorexia NervosaFecesHumansIntestine, SmallAnorexia nervosaBiomarkerFaecesMicrobiotaSpecies

Identifiers

PMID29542066
OpenAlexW2791219071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.