Evidence map›Paper›PMID 29541969›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2018

Improving sudden cardiac death risk stratification by evaluating electrocardiographic measures of global electrical heterogeneity and clinical outcomes among patients with implantable cardioverter-defibrillators: rationale and design for a retrospective, multicenter, cohort study.

Jonathan W Waks, Christopher Hamilton, Saumya Das, Ashkan Ehdaie, Jessica Minnier, Sanjiv Narayan, Mark Niebauer, Merritt Raitt, Christine Tompkins, Niraj Varma and 2 more

Registry-linked trialOpen access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03210883 (Global Electrical Heterogeneity and Clinical Outcomes), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03210883 completednot on this map

Global Electrical Heterogeneity and Clinical Outcomes

TypeobservationalSponsorLarisa TereshchenkoRan2017 to 2021Enrolled3,471ConditionsHeart Failure, Implantable Defibrillator User, Ventricular Arrythmia
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Competing risks of monomorphic vs. non-monomorphic ventricular arrhythmias in primary prevention implantable cardioverter-defibrillator recipients: Global Electrical Heterogeneity and Clinical Outcomes (GEHCO) study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 1 country.

Jonathan W WaksBeth Israel Deaconess Medical Center, Boston, MA, USA.
Christopher HamiltonKnight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA.
Saumya DasMassachusetts General Hospital, Boston, MA, USA.
Ashkan EhdaieCedars-Sinai Medical Center, Los Angeles, CA, USA.
Jessica MinnierKnight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA.
Sanjiv NarayanStanford University School of Medicine, Palo Alto, USA.
Mark NiebauerCleveland Clinic Foundation, Cleveland, OH, USA.
Merritt RaittVA Portland Health Care System, Portland, OR, USA.
Christine TompkinsUniversity of Colorado, Aurora, CO, USA.
Niraj VarmaCleveland Clinic Foundation, Cleveland, OH, USA.
Sumeet ChughCedars-Sinai Medical Center, Los Angeles, CA, USA.
Larisa G TereshchenkoBeth Israel Deaconess Medical Center, Boston, MA, USA. tereshch@ohsu.edu.
Cedars-Sinai Medical Center · USCleveland Clinic · USOregon Health & Science University · USBeth Israel Deaconess Medical Center · USMassachusetts General Hospital · USPalo Alto University · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Portland · USVA Portland Health Care System · US

Funding

OREGON CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024140 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2011
$61.1M
Novel ECG Measures and Risk of Sudden Cardiac DeathR01HL118277 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TERESHCHENKO, LARISA GENNADIEVNA · 2013 to 2016
$1.5M
Novel ECG measures and risk of sudden cardiac deathR56HL118277 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TERESHCHENKO, LARISA GENNADIEVNA · 2018 to 2018
$396k
American Heart Association 17GRNT33670428American Heart Association-American Stroke Association 17GRNT33670428NCRR NIH HHS UL1 RR024140NHLBI NIH HHS R01 HL118277NHLBI NIH HHS R56 HL118277
6 · The paper itself

Abstract

purposeImplantable cardioverter-defibrillators (ICDs) improve survival of systolic heart failure (HF) patients who are at risk of sudden cardiac death (SCD). We recently showed that electrocardiographic (ECG) global electrical heterogeneity (GEH) is independently associated with SCD in the community-dwelling cohort and developed GEH SCD risk score. The Global Electrical Heterogeneity and Clinical Outcomes (GEHCO) study is a retrospective multicenter cohort designed with two goals: (1) validate an independent association of ECG GEH with sustained ventricular tachyarrhythmias and appropriate ICD therapies and (2) validate GEH ECG risk score for prediction of sustained ventricular tachyarrhythmias and appropriate ICD therapies in systolic HF patients with primary prevention ICD.

methodsAll records of primary prevention ICD recipients with available data for analysis are eligible for inclusion. Records of ICD implantation in patients with inherited channelopathies and cardiomyopathies are excluded. Raw digital 12-lead pre-implant ECGs will be used to measure GEH (spatial QRST angle, spatial ventricular gradient magnitude, azimuth, and elevation, and sum absolute QRST integral). The primary endpoint is defined as a sustained ventricular tachyarrhythmia event with appropriate ICD therapy. All-cause death without preceding sustained ventricular tachyarrhythmia with appropriate ICD therapy will serve as a primary competing outcome. The study will draw data from the academic medical centers.

resultsWe describe the study protocol of the first multicenter retrospective cohort of primary prevention ICD patients with recorded at baseline digital 12-lead ECG.

conclusionFindings from this study will inform future trials to identify patients who are most likely to benefit from primary prevention ICD.

trial registrationURL: http://www.clinicaltrials.gov . Unique identifier: NCT03210883.

Indexed as

Academic Medical CentersAgedCohort StudiesDeath, Sudden, CardiacDefibrillators, ImplantableElectrocardiographyFemaleFollow-Up StudiesHeart Failure, SystolicHumansMaleMiddle AgedPatient SelectionRetrospective StudiesRisk AssessmentSurvival AnalysisElectrocardiogramImplantable cardioverter-defibrillatorsRisk stratificationSudden cardiac deathVectorcardiogramVentricular arrhythmias

Identifiers

PMID29541969
PMCPMC6556174
OpenAlexW2790958502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.