ArticleLangenbeck's archives of surgery2018
Is parathyroidectomy safe and effective in patients with normocalcemic primary hyperparathyroidism?
Article in Langenbeck's archives of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Kidney stone recurrence in hypercalcemic and normocalcemic primary hyperparathyroidism without parathyroidectomy.Endocrine connections · 2025Article
- Natural history and complications of normocalcemic hyperparathyroidism: a retrospective cohort study.JBMR plus · 2024Article
- Incidental Normocalcemic Primary Hyperparathyroidism Presenting With Symptomatic Hypophosphatemia: A Case Report.Cureus · 2023Article
- Comparative utility of preoperative imaging in normocalcemic versus hypercalcemic primary hyperparathyroidism.American journal of surgery · 2023Article
- Normocalcemic primary hyperparathyroidism.Archives of endocrinology and metabolism · 2022Review
- Elevated parathyroid hormone one year after kidney transplantation is an independent risk factor for graft loss even without hypercalcemia.BMC nephrology · 2022Article
- How should we define cure after parathyroidectomy for normocalcemic primary hyperparathyroidism? A retrospective cohort study.Updates in surgery · 2021Article
- Review
- Surgical management of MILD hyperparathyroidism.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Normocalcemic Primary Hyperparathyroidism: Need for a Standardized Clinical Approach.Endocrinology and metabolism (Seoul, Korea) · 2021Review
- Normocalcaemic primary hyperparathyroidism: what is the role of parathyroid surgery?Therapeutic advances in endocrinology and metabolism · 2021Review
- Normocalcaemic hyperparathyroidism and primary hyperparathyroidism: least significant change for adjusted serum calcium.European journal of endocrinology · 2021Article
- Review
- Normocalcemic Hyperparathyroidism: Study of its Prevalence and Natural History.The Journal of clinical endocrinology and metabolism · 2020Article
- Primary Hyperparathyroidism.The Journal of clinical endocrinology and metabolism · 2018Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeIndications and advantages of parathyroidectomy in patients with normocalcemic primary hyperparathyroidism (NHPT) are still matter of debate. We aimed to compare clinical presentation and surgical outcome between normocalcemic and hypercalcemic forms in a consecutive series of patients who underwent parathyroidectomy for primary hyperparathyroidism.
methodsData of 731 consecutive patients were reviewed and retrospectively compared according to normocalcemic (group A) and hypercalcemic (group B) phenotypes.
resultsNo significant differences were found between the two groups concerning demographics and symptomatic onset. Mean preoperative PTH levels were significantly higher in group B (252.0 ± 320.7 pg/ml vs 151.7 ± 112.0; p < 0.001). Mean PTH levels in first postoperative day were significantly lower in group B (30.9 ± 26.2 vs 22.7 ± 20.7; p < 0.001). No significant difference in overall accuracy of preoperative imaging studies was found. Significantly more patients in group A underwent bilateral explorations (83 vs 255; p < 0.05). The rate of multigland disease was significantly higher in group A (13.0 vs 6.8%; p < 0.05). At a mean follow-up period of 72.9 ± 46.8 months, all but three patients, among the 96 of group A who completed follow-up evaluation, were biochemically cured. The remaining patients had persistent high PTH values. Among NHPT patients who had target organ disease before parathyroidectomy, improvement in bone density and in kidney stones was observed in 41.7 and 40.0%, and stability in 50.0 and 60.0% respectively.
conclusionIn normocalcemic patients, parathyroidectomy is as safe and effective as in hypercalcemic patients. In the presence of symptoms and/or target organ disease, parathyroidectomy may have a positive effect on the outcome of NHPT patients.
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Registered trials
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