Evidence map›Paper›PMID 29541822›Full record

Observational studyWorld journal of surgery2018

Is Partial or Total Thyroidectomy Associated with Risk of Long-Term Osteoporosis: A Nationwide Population-Based Study.

Chien-Ling Hung, Chih-Ching Yeh, Pi-Shan Sung, Chung-Jye Hung, Chih-Hsin Muo, Fung-Chang Sung, I-Ming Jou, Kuen-Jer Tsai

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in World journal of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Total Thyroidectomy: Resection of Two Organs, Not Just One.Endocrinology and metabolism (Seoul, Korea) · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. TSH suppressive therapy and bone.Endocrine connections · 2020
    Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chien-Ling HungDepartment of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chih-Ching YehSchool of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan.
Pi-Shan SungInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, 704, Taiwan.
Chung-Jye HungDepartment of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chih-Hsin MuoManagement Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
Fung-Chang SungManagement Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
I-Ming JouDepartment of Orthopedics, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Kuen-Jer TsaiInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, 704, Taiwan. kjtsai@mail.ncku.edu.tw.ORCID http://orcid.org/0000-0002-2170-9735
National Cheng Kung University Hospital · TWChina Medical University · TWE-Da Hospital · TW

Funding

Academia Sinica Taiwan Biobank Stroke Biosignature Project BM10501010037Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence MOHW106-TDU-B-212-113004
6 · The paper itself

Abstract

backgroundWhether thyroidectomy contributes to osteoporosis (OP) and osteoporotic fracture (OF) is a subject of debate. This study aimed to determine the effect of thyroidectomy on the risk of OP and OF.

methodsThis retrospective cohort study is based on patient data between January 2000 to December 2005 from the National Health Insurance Research Database. Patients who underwent thyroidectomy were enrolled in the thyroidectomy cohort, and the control cohort was selected by propensity score matching at a ratio of 1:4. Incident OP and OF cases were identified until the end of 2013. The thyroidectomy cohort to control cohort adjusted hazard ratio (aHR) for OP/OF was assessed through multivariable Cox proportional hazard regression analysis.

resultsTotals of 1426 and 5704 patients were included in the thyroidectomy and control cohorts, respectively. The incidence density of OP was higher in the thyroidectomy cohort (7.91/1000 person-years) than in the control cohort (5.98/1000 person-years), with an aHR of 1.43 (95% CI 1.16-1.77, p < 0.05). Younger patients, women, and patients with comorbidities were at a higher risk. The risks of postoperative OP/OF were significantly increased in patients who received thyroxine treatment for more than 1 year, both in the partial thyroidectomy group and in the total and subtotal thyroidectomy group (aHR: 2.47, 95% CI: 1.42-2.31 vs. aHR: 1.84, 95% CI: 1.22-2.76).

conclusionThyroidectomy significantly increased the long-term risk of OP. Younger patients, women, patients with comorbidities, and patients receiving chronic thyroxin treatment should be monitored for changes in postoperative bone density.

Indexed as

AdultAgedBone DensityCohort StudiesComorbidityDatabases, FactualFemaleHumansIncidenceMaleMiddle AgedOsteoporosisPostoperative PeriodPropensity ScoreProportional Hazards ModelsResearch Design

Identifiers

PMID29541822
OpenAlexW2791275032

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.