ArticleJournal of diabetes research2018
Low Birth Weight, Cumulative Obesity Dose, and the Risk of Incident Type 2 Diabetes.
Article in Journal of diabetes research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Training in motivational interviewing for pediatricians was associated with a higher uptake of health behavior and lifestyle treatment: Results from the KP Wellness Coaching for Families and Kids (WC4K) Program.Patient education and counseling · 2025Trial
- Evaluating the Effectiveness of the Motivational Interviewing-Based Wellness Coaching for Kids and Families (WC4K) Program in Pediatric Obesity Care: Protocol for a Cluster Randomized Pragmatic Trial.JMIR research protocols · 2026Article
- Temporal trends in birthweight and its association with overweight/obesity in schoolchildren from a Brazilian city: a cross-sectional panel study (2002-2019).Sao Paulo medical journal = Revista paulista de medicina · 2026Article
- Fetal Pancreas in Growth Restriction: A Prenatal Window Into Metabolic and Genetic Risk.Prenatal diagnosis · 2025Article
- Article
- Transgenerational Inheritance and Systemic Racism in America.Psychiatric research and clinical practice · 2023Review
- Gestational Weight Gain and Small for Gestational Age in Obese Women: A Systematic Review and Meta-Analysis.International journal of endocrinology · 2023Review
- Associations Between Rurality, pre-pregnancy Health Status, and Macrosomia in American Indian/Alaska Native Populations.Maternal and child health journal · 2022Article
- Association of preconception mixtures of phenol and phthalate metabolites with birthweight among subfertile couples.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- The role of CD36-Fabp4-PPARγ in skeletal muscle involves insulin resistance in intrauterine growth retardation mice with catch-up growth.BMC endocrine disorders · 2022Article
- The Early Life Course of Body Weight and Gene Expression Signatures for Disease.American journal of epidemiology · 2021Article
- Life-course trajectories of weight and their impact on the incidence of type 2 diabetes.Scientific reports · 2021Observational
- Prospective cohort studies of birth weight and risk of obesity, diabetes, and hypertension in adulthood among the Chinese population.Journal of diabetes · 2019Article
- Non-communicable disease risk factor profile among public employees in a regional city in northern Ethiopia.Scientific reports · 2018Article
- Early-life nutrition and adult-life outcomes.Jornal de pediatriaReview
Corrections and comments
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity history may provide a better understanding of the contribution of obesity to T2DM risk.
methods17,634 participants from the 1958 National Child Development Study were followed from birth to 50 years. Cumulative obesity dose, a measure of obesity history, was calculated by subtracting the upper cut-off of the normal BMI from the actual BMI at each follow-up and summing the areas under the obesity dose curve. Hazard ratios (HRs) for diabetes were calculated using Cox regression analysis. Three separate models compared the predictive ability of cumulative obesity dose on diabetes risk with the time-varying BMI and last BMI.
resultsIn final models, 341 of 15,043 (2.27%) participants developed diabetes; male sex and low birth weight were significant confounding variables. Adjusted HRs were 1.080 (95% CI: 1.071, 1.088) per 10-unit cumulative obesity dose, 1.098 (95% CI: 1.080, 1.117) per unit of the time-varying BMI, and 1.146 (95% CI: 1.084, 1.212) per unit of the last BMI. Cumulative obesity dose provided the best predictive ability for diabetes.
conclusionsCumulative obesity dose is an improved method for evaluating the impact of obesity history on diabetes risk. The link between low birth weight and T2DM is strengthened by adjusting for cumulative obesity dose.
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