ArticleIEEE journal of translational engineering in health and medicine2018
Evaluation of Ventilation-Induced Lung Inflammation Through Multi-Scale Simulations.
Article in IEEE journal of translational engineering in health and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Mathematical modeling of ventilator-induced lung inflammation.Journal of theoretical biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ventilation-induced lung injury is a common problem faced by patients with respiratory problems who require mechanical ventilation (MV). This injury may lead to a greater chance of developing or exacerbating the acute respiratory distress syndrome which further complicates the therapeutic use of MV. The chain of events begins with the MV initiating an immune response that leads to inflammation induced tissue material alteration (stiffening) and eventually the loss of lung resistance. It is clear from this sequence of events that the phenomenon of ventilation induced injury is multi-scale by nature and, hence, requires holistic analysis involving simulations and informatics. An effective approach to this problem is to break it down into several major physical models. Each physical model is developed separately and can be seen as a component in a larger system that comprises the scale of the problem being investigated. In this paper, a multi-scale system consisting of breathing mechanics, tissue deformation, and cellular mechanics models is developed to assess the immune response. To demonstrate the potential of the model, a fluid-solid model is employed for breathing mechanics, a plane-strain elasticity model is applied to assess tissue deformation, and a cellular automata (CA) model is developed to account for immune response. A case study of three lower airways is presented. The CA model shows that this increased the immune response by five times, which correlates with alteration in the tissue microstructure. This alteration in turn is reflected in the material constant value obtained in the tissue mechanics model. However, the changes in strain rates in the airways after inflammation (and hence, lung compliance) were not as significant as the rates of change in immune response. Finally, results from the fluid-solid model demonstrate its potential for airflow characterization caused by tissue deformation that could lead to disease identification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.