Evidence map›Paper›PMID 29541538›Full record

ArticleBrain and behavior2018

Transcranial DC stimulation modifies functional connectivity of large-scale brain networks in abstinent methamphetamine users.

Alireza Shahbabaie, Mitra Ebrahimpoor, Ali Hariri, Michael A Nitsche, Javad Hatami, Emad Fatemizadeh, Mohammad Ali Oghabian, Hamed Ekhtiari

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In one paragraph

Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  2. A systematic review and meta-analysis of neuromodulation therapies for substance use disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alireza ShahbabaieInstitute for Cognitive Science Studies Tehran Iran.
Mitra EbrahimpoorNeuroimaging and Analysis Group Research Center for Cellular and Molecular Imaging Tehran University of Medical Sciences Tehran Iran.
Ali HaririDepartment of Nano Engineering and Materials Science and Engineering Program University of California San Diego La Jolla CA USA.
Michael A NitscheDepartment of Psychology and Neurosciences Leibniz Research Center for Working Environment and Human Factors Dortmund Germany.
Javad HatamiInstitute for Cognitive Science Studies Tehran Iran.
Emad FatemizadehDepartment of Electrical Engineering Sharif University of Technology Tehran Iran.
Mohammad Ali OghabianNeuroimaging and Analysis Group Research Center for Cellular and Molecular Imaging Tehran University of Medical Sciences Tehran Iran.
Hamed EkhtiariInstitute for Cognitive Science Studies Tehran Iran.ORCID 0000-0001-6902-8798

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation tool suited to alter cortical excitability and activity via the application of weak direct electrical currents. An increasing number of studies in the addiction literature suggests that tDCS modulates subjective self-reported craving through stimulation of dorsolateral prefrontal cortex (DLPFC). The major goal of this study was to explore effects of bilateral DLPFC stimulation on resting state networks (RSNs) in association with drug craving modulation. We targeted three large-scale RSNs; the default mode network (DMN), the executive control network (ECN), and the salience network (SN). Methods: Fifteen males were recruited after signing written informed consent. We conducted a double-blinded sham-controlled crossover study. Twenty-minute "real" and "sham" tDCS (2 mA) were applied over the DLPFC on two separate days in random order. Each subject received both stimulation conditions with a 1-week washout period. The anode and cathode electrodes were located over the right and left DLPFC, respectively. Resting state fMRI was acquired before and after real and sham stimulation. Subjective craving was assessed before and after each fMRI scan. The RSNs were identified using seed-based analysis and were compared using a generalized linear model. Results: Subjective craving decreased significantly after real tDCS compared to sham stimulation ( Discussion: Given the observed alteration of the targeted functional brain networks in methamphetamine users, new potentials are highlighted for tDCS as a network intervention strategy and rsfMRI as a suitable monitoring method for these interventions.

Indexed as

MethamphetamineAdultAmphetamine-Related DisordersBrainCentral Nervous System StimulantsCravingCross-Over StudiesDouble-Blind MethodHumansLinear ModelsMagnetic Resonance ImagingMaleTranscranial Direct Current StimulationTreatment OutcomeCentral Nervous System StimulantsMethamphetaminefunctional connectivitylarge‐scale brain networksmethamphetamine cravingnoninvasive brain stimulationresting state fMRItranscranial direct current stimulation

Identifiers

PMID29541538
PMCPMC5840443

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.