Evidence map›Paper›PMID 29541519›Full record

ArticleBiomedical optics express2018

Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke.

Raquel Delgado-Mederos, Clara Gregori-Pla, Peyman Zirak, Igor Blanco, Lavinia Dinia, Rebeca Marín, Turgut Durduran, Joan Martí-Fàbregas

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Cerebral Blood Flow Response During Bolus Normal Saline Infusion After Ischemic Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019
    Trial
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  8. Perfusion Enhancement with Respiratory Impedance After Stroke (PERI-Stroke).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019
    Article
  9. Continuous non-invasive optical monitoring of cerebral blood flow and oxidative metabolism after acute brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Observational
  10. Transcranial Optical Monitoring of Cerebral Hemodynamics in Acute Stroke Patients during Mechanical Thrombectomy.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019
    Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Raquel Delgado-MederosDepartment of Neurology, Hospital de la Santa Creu i Sant Pau, C. Sant Antoni M Claret 167, 08025, Barcelona, Spain.
Clara Gregori-PlaICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Av. Carl Friedrich Gauss 3, Castelldefels (Barcelona), 08860, Spain.
Peyman ZirakICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Av. Carl Friedrich Gauss 3, Castelldefels (Barcelona), 08860, Spain.
Igor BlancoICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Av. Carl Friedrich Gauss 3, Castelldefels (Barcelona), 08860, Spain.
Lavinia DiniaDepartment of Neurology, Hospital de la Santa Creu i Sant Pau, C. Sant Antoni M Claret 167, 08025, Barcelona, Spain.
Rebeca MarínDepartment of Neurology, Hospital de la Santa Creu i Sant Pau, C. Sant Antoni M Claret 167, 08025, Barcelona, Spain.
Turgut DurduranICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Av. Carl Friedrich Gauss 3, Castelldefels (Barcelona), 08860, Spain.
Joan Martí-FàbregasDepartment of Neurology, Hospital de la Santa Creu i Sant Pau, C. Sant Antoni M Claret 167, 08025, Barcelona, Spain.
Hospital de Sant Pau · ESInstitute of Photonic Sciences · ESInstitució Catalana de Recerca i Estudis Avançats · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this pilot study, we have evaluated bedside diffuse optical monitoring combining diffuse correlation spectroscopy and near-infrared diffuse optical spectroscopy to assess the effect of thrombolysis with an intravenous recombinant tissue plasminogen activator (rtPA) on cerebral hemodynamics in an acute ischemic stroke. Frontal lobes of five patients with an acute middle cerebral artery occlusion were measured bilaterally during rtPA treatment. Both ipsilesional and contralesional hemispheres showed significant increases in cerebral blood flow, total hemoglobin concentration and oxy-hemoglobin concentration during the first 2.5 hours after rtPA bolus. The increases were faster and higher in the ipsilesional hemisphere. The results show that bedside optical monitoring can detect the effect of reperfusion therapy for ischemic stroke in real-time.

Indexed as

(170.0170) Medical optics and biotechnology(170.1470) Blood or tissue constituent monitoring(170.6510) Spectroscopy, tissue diagnostics

Identifiers

PMID29541519
PMCPMC5846529
OpenAlexW2788551788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.