ArticleBiomedical optics express2018
Wide-field quantitative micro-elastography of human breast tissue.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026Review
- A wireless and handheld optical palpation imaging probe for use in breast-conserving surgery.APL bioengineering · 2026Article
- Development of breast-mimicking phantoms for use in optical coherence elastography.Journal of biomedical optics · 2025Article
- Diagnostic feasibility study of stereoscopic optical palpation for breast tumour margin assessment.BMC cancer · 2025Article
- Three-dimensional dynamic optical coherence tomography for breast tumor margin assessment.Biomedical optics express · 2025Article
- Wide-field quantitative micro-elastography of freshly excised human prostate.Biomedical optics express · 2025Article
- Design and characterization of an optical phantom for mesoscopic multimodal fluorescence lifetime imaging and optical coherence elastography.Biomedical optics express · 2025Article
- Imaging of prostate micro-architecture using three-dimensional wide-field optical coherence tomography.Biomedical optics express · 2024Article
- Multimodal mechano-microscopy reveals mechanical phenotypes of breast cancer spheroids in three dimensions.APL bioengineering · 2024Article
- A novel stress sensor enables accurate estimation of micro-scale tissue mechanics in quantitative micro-elastography.APL bioengineering · 2024Article
- Laser speckle rheological microscopy reveals wideband viscoelastic spectra of biological tissues.Science advances · 2024Article
- Compressed sensing of human breast optical coherence 3-D image volume data using predictive coding.Biomedical optics express · 2023Article
- Analysis of friction in quantitative micro-elastography.Biomedical optics express · 2023Article
- Recent advances in optical elastography and emerging opportunities in the basic sciences and translational medicine [Invited].Biomedical optics express · 2023Review
- Quantitative Micro-Elastography Enables In Vivo Detection of Residual Cancer in the Surgical Cavity during Breast-Conserving Surgery.Cancer research · 2022Article
- Three-dimensional mechanical characterization of murine skeletal muscle using quantitative micro-elastography.Biomedical optics express · 2022Article
- Multi-class classification of breast tissue using optical coherence tomography and attenuation imaging combined via deep learning.Biomedical optics express · 2022Article
- Nonlinear Elasticity Assessment with Optical Coherence Elastography for High-Selectivity Differentiation of Breast Cancer Tissues.Materials (Basel, Switzerland) · 2022Article
- Multimodal Optical Coherence Tomography for Intraoperative Evaluation of Tumor Margins and Surgical Margins in Breast-Conserving Surgery.Sovremennye tekhnologii v meditsine · 2022Article
- Rapid non-destructive volumetric tumor yield assessment in fresh lung core needle biopsies using polarization sensitive optical coherence tomography.Biomedical optics express · 2021Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to insufficient surgical margins in the initial procedure. We have developed a wide-field quantitative micro-elastography system for the assessment of tumor margins. In this technique, we map tissue elasticity over a field-of-view of ~46 × 46 mm. We performed wide-field quantitative micro-elastography on thirteen specimens of freshly excised tissue acquired from patients undergoing a mastectomy. We present wide-field optical coherence tomography (OCT) images, qualitative (strain) micro-elastograms and quantitative (elasticity) micro-elastograms, acquired in 10 minutes. We demonstrate that wide-field quantitative micro-elastography can extend the range of tumors visible using OCT-based elastography by providing contrast not present in either OCT or qualitative micro-elastography and, in addition, can reduce imaging artifacts caused by a lack of contact between tissue and the imaging window. Also, we describe how the combined evaluation of OCT, qualitative micro-elastograms and quantitative micro-elastograms can improve the visualization of tumor.
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