Evidence map›Paper›PMID 29541496›Full record

ArticleBiomedical optics express2018

Phase-stable Doppler OCT at 19 MHz using a stretched-pulse mode-locked laser.

Serhat Tozburun, Cedric Blatter, Meena Siddiqui, Eelco F J Meijer, Benjamin J Vakoc

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

  1. Journal of biophotonics · 2025
    Article
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  4. Optical coherence tomography.Nature reviews. Methods primers · 2022
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  10. Biomedical optics express · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Serhat TozburunHarvard Medical School, Boston, Massachusetts 02115, USA.
Cedric BlatterHarvard Medical School, Boston, Massachusetts 02115, USA.
Meena SiddiquiWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Eelco F J MeijerHarvard Medical School, Boston, Massachusetts 02115, USA.
Benjamin J VakocHarvard Medical School, Boston, Massachusetts 02115, USA.
Harvard University · USMassachusetts General Hospital · US

Funding

TRD3: Percutaneous and Interstitial ImagingP41EB015903 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Brett E Bouma · 2012 to 2026
$22.4M
Development of a preclinical optical frequency domain angiography instrumentR01CA163528 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI VAKOC, BENJAMIN JAMES · 2012 to 2016
$1.9M
NCI NIH HHS R01 CA163528NIBIB NIH HHS P41 EB015903
6 · The paper itself

Abstract

We present a swept-wavelength optical coherence tomography (OCT) system with a 19 MHz laser source and electronic phase-locking of the source, acquisition clock, and beam scanning mirrors. The laser is based on stretched-pulse active mode-locking using an electro-optic modulator. Beam scanning in the fast axis uses a resonant micro-electromechanical systems (MEMS) -based mirror at ~23.8 kHz. Acquisition is performed at 1.78 Gigasamples per second using an external fixed clock. Phase sensitive imaging without need for k-clocking, A-line triggers, or phase-calibration methods is demonstrated. The system was used to demonstrate inter-frame and inter-volume Doppler imaging in the mouse ear and brain at 4D acquisition rates of 1, 30, 60 and 100 volumes/sec (V-scans/s). Angiography based on inter-frame and inter-volume methods are presented. The platform offers extremely fast and phase-stable measurements that can be used in preclinical angiographic and Doppler investigations of perfusion dynamics.

Indexed as

(140.3600) Lasers, tunable(170.0110) Imaging systems(170.4500) Optical coherence tomography

Identifiers

PMID29541496
PMCPMC5846541
OpenAlexW2786800297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.