Evidence map›Paper›PMID 29541475›Full record

ArticlePharmacology research & perspectives2018

Metformin normalizes the structural changes in glycogen preceding prediabetes in mice overexpressing neuropeptide Y in noradrenergic neurons.

Liisa Ailanen, Natalia N Bezborodkina, Laura Virtanen, Suvi T Ruohonen, Anastasia V Malova, Sergey V Okovityi, Elizaveta Y Chistyakova, Eriika Savontaus

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Liisa AilanenInstitute of Biomedicine Research Center for Integrative Physiology and Pharmacology and Turku Center for Disease Modelling University of Turku Turku Finland.
Natalia N BezborodkinaLaboratory of Cellular Pathology Institute of Cytology of the Russian Academy of Sciences St. Petersburg Russia.
Laura VirtanenInstitute of Biomedicine Research Center for Integrative Physiology and Pharmacology and Turku Center for Disease Modelling University of Turku Turku Finland.
Suvi T RuohonenInstitute of Biomedicine Research Center for Integrative Physiology and Pharmacology and Turku Center for Disease Modelling University of Turku Turku Finland.
Anastasia V MalovaLaboratory of Cellular Pathology Institute of Cytology of the Russian Academy of Sciences St. Petersburg Russia.
Sergey V OkovityiDepartment of Pharmacology and Clinical Pharmacology Saint-Petersburg State Chemical Pharmaceutical Academy St. Petersburg Russia.
Elizaveta Y ChistyakovaDepartment of Pharmacology and Clinical Pharmacology Saint-Petersburg State Chemical Pharmaceutical Academy St. Petersburg Russia.
Eriika SavontausInstitute of Biomedicine Research Center for Integrative Physiology and Pharmacology and Turku Center for Disease Modelling University of Turku Turku Finland.ORCID 0000-0003-3421-0367
University of Turku · FIInstitute of Cytology · RUSaint - Petersburg State Chemical Pharmaceutical Academy · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic insulin resistance and increased gluconeogenesis are known therapeutic targets of metformin, but the role of hepatic glycogen in the pathogenesis of diabetes is less clear. Mouse model of neuropeptide Y (NPY) overexpression in noradrenergic neurons (OE-NPY

Indexed as

Adrenergic NeuronsAnimalsDiabetes Mellitus, ExperimentalGlycogenHepatocytesHypoglycemic AgentsMaleMetforminMice, TransgenicNeuropeptide YPhosphorylationPrediabetic StateUp-RegulationGlycogenHypoglycemic AgentsMetforminNeuropeptide Yglycogen structuremetforminneuropeptide Yprediabetes

Identifiers

PMID29541475
PMCPMC5842371
OpenAlexW2794328218

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.