Evidence map›Paper›PMID 29541450›Full record

ArticleAnnals of medicine and surgery (2012)2018

Gastric fundus submucosa as a site for islets transplantation: An experimental study.

Gustavo Heluani Antunes de Mesquita, Yuri Justi Jardim, Leandro Ryuchi Iuamoto, Fabio Yuji Suguita, Felipe Futema Essu, Lucas Torres Oliveira, Alberto Meyer, Alessandra Crescenzi, Vinícius Rocha-Santos, Flavio H F Galvão and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine and surgery (2012), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Gustavo Heluani Antunes de MesquitaFaculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.
Yuri Justi JardimFaculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.
Leandro Ryuchi IuamotoFaculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.
Fabio Yuji SuguitaFaculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.
Felipe Futema EssuFaculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.
Lucas Torres OliveiraFaculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.
Alberto MeyerDepartamento de Gastroenterologia, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Alessandra CrescenziDivisão de Transplante de Fígado, LIM 37, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Vinícius Rocha-SantosDivisão de Transplante de Fígado, LIM 37, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Flavio H F GalvãoDivisão de Transplante de Fígado, LIM 37, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Wellington AndrausDepartamento de Gastroenterologia, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Eleazar ChaibDivisão de Transplante de Fígado, LIM 37, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Luiz Augusto Carneiro D'AlbuquerqueDepartamento de Gastroenterologia, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIslets of Langerhans transplantation is a promising alternative for glycemic control in patients with type 1 diabetes. The graft site is a factor that has large impact on the functioning of this transplant, and the stomach appears to be a promising location. Our objective is to describe a new experimental model for the grafting of Islets of Langerhans in rat stomachs. METHODOLOGY: Islets of Langerhans were extracted from 45 isogenic male rats of the Lewis lineage and transplanted into 9 isogenic rats of the Wistar lineage; 5 in the gastric body submucosa, and 4 in the gastric fundus submucosa. Normoglycemia was defined as two successive measurements of <250 mg/dL. No immunosuppression was used. The two groups glycemia control improvement were compared with

resultsThe results obtained following the transplantation of the islets in 9 rats showed between 995 and 2310 islets transplanted (mean of 1367). The rats from the gastric submucosa group had a better glycemic level improvement, with a confidence equal to 83.94%.

conclusionIslets graft into the gastric fundus submucosa is a viable model with potential for adequate glycemic control. This model gives potential for new perspectives and future studies in this area.

Indexed as

Gastric fundus submucosaIslets transplantationType 1 diabetes

Identifiers

PMID29541450
PMCPMC5849781
OpenAlexW2793203041

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.