ArticleMolecular autism2018
Network-specific sex differentiation of intrinsic brain function in males with autism.
Article in Molecular autism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 69 citations in OpenAlex.
- Brain morphology network profiles in male and female youth with autism.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Humour as emotion regulation and resource in autism: a narrative review.Frontiers in psychiatry · 2026Review
- A Proposal for Terminology for Clear Communication and Avoidance of Confusion in Relation to Sex, the Social Expectations of the Sexes and Gender Identity.Archives of sexual behavior · 2025Article
- Sex differences in trajectories of cortical development in autistic children from 2-13 years of age.Molecular psychiatry · 2024Article
- Sex modulation of faces prediction error in the autistic brain.Communications biology · 2024Article
- The impact of quality control on cortical morphometry comparisons in autism.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Article
- Altered brain network organization in adults with Asperger's syndrome: decreased connectome transitivity and assortativity with increased global efficiency.Frontiers in psychiatry · 2023Article
- Acute cannabidiol treatment enhances social interaction in adult male mice.Advances in drug and alcohol research · 2023Article
- Is there an association between prenatal testosterone and autistic traits in adolescents?Psychoneuroendocrinology · 2022Article
- An auditory processing advantage enables communication in less complex social settings: Signs of an extreme female brain in children and adolescents being assessed for Autism Spectrum Disorders.Frontiers in psychology · 2022Article
- Sex Differences in Autism Spectrum Disorder: Diagnostic, Neurobiological, and Behavioral Features.Frontiers in psychiatry · 2022Review
- Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization.Molecular psychiatry · 2021Article
- Performance of machine learning classification models of autism using resting-state fMRI is contingent on sample heterogeneity.Neural computing & applications · 2021Article
- Towards robust and replicable sex differences in the intrinsic brain function of autism.Molecular autism · 2021Article
- Difference in default mode network subsystems in autism across childhood and adolescence.Autism : the international journal of research and practice · 2021Article
- Sex Differences in Autism Spectrum Disorder: Focus on High Functioning Children and Adolescents.Frontiers in psychiatry · 2021Article
- Extraction and Evaluation of Corpus Callosum from 2D Brain MRI Slice: A Study with Cuckoo Search Algorithm.Computational and mathematical methods in medicine · 2021Article
- Ultra-high field (10.5 T) resting state fMRI in the macaque.NeuroImage · 2020Article
- Foetal oestrogens and autism.Molecular psychiatry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Background: The male predominance in the prevalence of autism spectrum disorder (ASD) has motivated research on sex differentiation in ASD. Multiple sources of evidence have suggested a neurophenotypic convergence of ASD-related characteristics and typical sex differences. Two existing, albeit competing, models provide predictions on such neurophenotypic convergence. These two models are testable with neuroimaging. Specifically, the Extreme Male Brain (EMB) model predicts that ASD is associated with enhanced brain maleness in both males and females with ASD (i.e., a shift-towards-maleness). In contrast, the Gender Incoherence (GI) model predicts a shift-towards-maleness in females, yet a shift-towards-femaleness in males with ASD. Methods: To clarify whether either model applies to the intrinsic functional properties of the brain in males with ASD, we measured the statistical overlap between typical sex differences and ASD-related atypicalities in resting-state fMRI (R-fMRI) datasets largely available in males. Main analyses focused on two large-scale R-fMRI samples: 357 neurotypical (NT) males and 471 NT females from the 1000 Functional Connectome Project and 360 males with ASD and 403 NT males from the Autism Brain Imaging Data Exchange. Results: Across all R-fMRI metrics, results revealed coexisting, but network-specific, shift-towards-maleness and shift-towards-femaleness in males with ASD. A shift-towards-maleness mostly involved the default network, while a shift-towards-femaleness mostly occurred in the somatomotor network. Explorations of the associated cognitive processes using available cognitive ontology maps indicated that higher-order social cognitive functions corresponded to the shift-towards-maleness, while lower-order sensory motor processes corresponded to the shift-towards-femaleness. Conclusions: The present findings suggest that atypical intrinsic brain properties in males with ASD partly reflect mechanisms involved in sexual differentiation. A model based on network-dependent atypical sex mosaicism can synthesize prior competing theories on factors involved in sex differentiation in ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.