Evidence map›Paper›PMID 29541391›Full record

ArticleOncotarget2018

Acute myeloid leukemia with t(4;12)(q12;p13): an aggressive disease with frequent involvement of

Jingyi Li, Jie Xu, Lynne V Abruzzo, Guilin Tang, Shaoying Li, M James You, Gary Lu, Elias J Jabbour, Qi Deng, Carlos E Bueso-Ramos and 2 more

Erratum issuedAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Acute myeloid leukemia with a novelLeukemia research reports · 2024
    Article
  3. Article
  4. Rare evolution ofLeukemia research reports · 2022
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jingyi LiDepartment of Hematopathology, Tianjin First Center Hospital, Tianjin, China.
Jie XuDepartment of Hematopathology, Tianjin First Center Hospital, Tianjin, China.
Lynne V AbruzzoDepartment of Hematopathology, Tianjin First Center Hospital, Tianjin, China.
Guilin TangDepartment of Hematopathology, Tianjin First Center Hospital, Tianjin, China.
Shaoying LiDepartment of Hematopathology, Tianjin First Center Hospital, Tianjin, China.
M James YouDepartment of Hematopathology, Tianjin First Center Hospital, Tianjin, China.
Gary LuDepartment of Hematopathology, Tianjin First Center Hospital, Tianjin, China.
Elias J JabbourDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Qi DengDepartment of Hematology, Tianjin First Center Hospital, Tianjin, China.
Carlos E Bueso-RamosDepartment of Hematopathology, Tianjin First Center Hospital, Tianjin, China.
L Jeffrey MedeirosDepartment of Hematopathology, Tianjin First Center Hospital, Tianjin, China.
C Cameron YinDepartment of Hematopathology, Tianjin First Center Hospital, Tianjin, China.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
NCI NIH HHS P30 CA016058
6 · The paper itself

Abstract

We describe the clinical, morphologic, immunophenotypic and molecular genetic features of 15 cases of acute myeloid leukemia (AML) with t(4;12)(q12;p13). There were 9 men and 6 women, with a median age of 50 years (range, 17-76). Most patients had hypercellular bone marrow with a median blast count of 58% and multilineage dysplasia. Flow cytometry analysis showed myeloid lineage with blasts positive for CD13, CD33, CD34, CD38, CD117 and HLA-DR. Interestingly, aberrant CD7 expression was detected in 12/14 cases, and myeloperoxidase was either negative (3/15) or positive in only a small subset of the blasts (12/15). t(4;12)(q12;p13) was detected at time of initial diagnosis in 4 and at relapse or progression in 9 patients. The initial karyotype was unknown in 2 cases. FISH analysis showed

Indexed as

acute myeloid leukemiaETV6PDGFRAt(4;12)(q12;p13)

Identifiers

PMID29541391
PMCPMC5834280

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.