Evidence map›Paper›PMID 29541358›Full record

ArticleACS medicinal chemistry letters2018

Synthesis and Evaluation of Pyridyloxypyridyl Indole Carboxamides as Potential PET Imaging Agents for 5-HT

Fanxing Zeng, Jonathon A Nye, Ronald J Voll, Leonard Howell, Mark M Goodman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Imaging the 5-HTJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Article
  3. Radiotracers for the Central Serotoninergic System.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  4. Synthesis and Evaluation of [Frontiers in neuroscience · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fanxing ZengDepartment of Radiology and Imaging Sciences, Center for Systems Imaging, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, United States.
Jonathon A NyeDepartment of Radiology and Imaging Sciences, Center for Systems Imaging, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, United States.
Ronald J VollDepartment of Radiology and Imaging Sciences, Center for Systems Imaging, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, United States.
Leonard HowellDepartment of Radiology and Imaging Sciences, Center for Systems Imaging, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, United States.
Mark M GoodmanDepartment of Radiology and Imaging Sciences, Center for Systems Imaging, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, United States.

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
NIH HHS P51 OD011132
6 · The paper itself

Abstract

Nine pyridyloxypyridyl indole carboxamides were synthesized and displayed high affinities for 5-HT

Identifiers

PMID29541358
PMCPMC5846131

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.