Evidence map›Paper›PMID 29541164›Full record

ReviewDiabetology & metabolic syndrome2018

The effects of exercise on vascular endothelial function in type 2 diabetes: a systematic review and meta-analysis.

Jung-Hoon Lee, Ruda Lee, Moon-Hyon Hwang, Marc T Hamilton, Yoonjung Park

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetology & metabolic syndrome, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 8 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 8 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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  15. Impact of Diabetes on Long-Term Outcomes of Percutaneous Coronary Intervention for Coronary Bifurcation Lesions.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jung-Hoon Lee1Laboratory of Human Physiology, Korea National Sport University, Seoul, Republic of Korea.
Ruda Lee2Exercise & Cardiovascular Physiology Laboratory, Division of Health and Exercise Science, Incheon National University, Incheon, Republic of Korea.
Moon-Hyon Hwang2Exercise & Cardiovascular Physiology Laboratory, Division of Health and Exercise Science, Incheon National University, Incheon, Republic of Korea.
Marc T Hamilton4Texas Obesity Research Center from the Division of Research, and Department of Health and Human Performance, University of Houston, Houston, TX USA.
Yoonjung Park5Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman St, Houston, TX 77204-6015 USA.
Incheon National University · KRUniversity of Houston · USKorea National Sport University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVascular endothelial dysfunction induced by hyperglycemia and elevated insulin resistance is a potent risk factor for cardiovascular disease and likely contributes to multiple chronic disease complications associated with aging. The aim of this study was to systematically review and quantify the effects of exercise on endothelial function (EF) in type 2 diabetes (T2D).

methodsFive electronic databases were searched (until June 2017) for studies that met the following criteria: (i) randomized controlled trials; (ii) T2D aged ≥ 18 years; (iii) measured EF by brachial artery flow-mediated dilation (FMD); (iv) structured and supervised exercise intervention for ≥ 8 weeks.

resultsThirteen cohorts, selected from eight studies (306 patients, average age 59 years), met the inclusion criteria. Exercise training significantly increased FMD (mean ES = 0.41, 95% CI 0.21-0.62,

conclusionOur results suggest that in patients with T2D, lower intensity exercise has physiological meaningful effects on EF, in support of the emerging concept that the lower efforts of exercise are not necessarily less cardioprotective than higher intensity training.

Indexed as

Endothelial functionExercise trainingFlow mediated dilationLow intensity exerciseNO bioavailabilitySedentaryType 2 diabetes

Identifiers

PMID29541164
PMCPMC5840787
OpenAlexW2797403850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.