Evidence map›Paper›PMID 29541037›Full record

ArticleFrontiers in psychiatry2018

Serum Brain-Derived Neurotrophic Factor, and Plasma Catecholamine Metabolites in People with Major Depression: Preliminary Cross-Sectional Study.

Reiji Yoshimura, Taro Kishi, Kiyokazu Atake, Asuka Katsuki, Nakao Iwata

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Reiji YoshimuraDepartment of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Taro KishiDepartment of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Japan.
Kiyokazu AtakeDepartment of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Asuka KatsukiDepartment of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Nakao IwataDepartment of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Japan.
University of Occupational and Environmental Health Japan · JPFujita Health University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are complicated interactions between catecholaminergic neurons and brain-derived neurotrophic factor (BDNF) in the brain. However, no reports have addressed the relationship among 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and BDNF in the blood.

objectiveThis paper sought to investigate correlations between serum BDNF and plasma levels of MHPG and HVA in people with major depression (MD). MATERIALS AND

methodsA total of 148 patients (male/female 65/83, age 49.5 ± 12.1 years old) who satisfied criteria for MD based on the Diagnostic and Statistical Manual of Mental Disorders IV were enrolled in the present study. Plasma levels of MHPG and HVA were analyzed using high-performance liquid chromatography, and serum BDNF was measured using ELISA.

resultsNo interactions were observed between plasma HVA levels (mean ± SD = 4.5 ± 1.5 ng/mL) and age, sex, HAMD scores, or serum BDNF levels (mean ± SD = 9.8 ± 2.9 ng/mL). No correlations were not also observed between plasma MHPG levels (mean ± SD = 5.9 ± 2.1 ng/mL) and age, sex, the HAMD17 scores (mean ± SD = 22.2 ± 2.9 ng/mL), or serum BDNF levels. Serum BDNF levels were negatively associated with HAMD17 scores.

conclusionThe results suggest that there are no significant correlations between catecholamine metabolites and BDNF in the blood for MDD patients.

Indexed as

3-methoxy-4-hydroxyphenylglycolbrain-derived neurotrophic factorhomovanillic acidmajor depressionplasmaserum

Identifiers

PMID29541037
PMCPMC5835900
OpenAlexW2794173711

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.